用于在临床和研究环境中使用的核心结果测量仪器,用于患有COVID-19后疾病的成年人:国际Delphi共识研究研究
Sarah L Gorst1, Nina Seylanova2, Susanna R Dodd1
1MRC-NIHR Trials Methodology Research Partnership, Department of Health Data Science, University of Liverpool, Liverpool, UK.
The Lancet. Respiratory medicine
|November 5, 2023
概括
为COVID-19后状态 (长期COVID) 开发一个核心结果测量集 (COMS) 涉及世界各地的专家和患者. 在一些措施上达成共识,为评估长期COVID症状和加速研究提供了基础.
科学领域:
- 医学研究 医学研究
- 公共卫生 公共卫生
- 临床试验 临床试验
背景情况:
- 后COVID-19状态,或长期COVID,是一个复杂和新兴的健康问题.
- 长期COVID结果的标准化测量对于临床护理和研究至关重要.
- 之前开发的核心成果集 (COS) 需要经过验证的测量仪器.
研究的目的:
- 为了建立一个核心结果测量集 (COMS) 后COVID-19条件在成年人.
- 确定和达成对核心长期COVID结果的测量仪器的共识.
- 为持续评估和研究长期COVID提供基础.
主要方法:
- 国际共识研究涉及多学科专家和具有长期COVID经验的个人.
- 文献审查以确定12个核心结果的测量工具.
- 三轮在线修改的Delphi过程和一个在线共识会议.
主要成果:
- 来自58个国家的594名参与者为共识进程做出了贡献.
- 审查了319个潜在的工具,其中19个被列为入围名单.
- 对修改后的医学研究理事会呼吸不良量表 (呼吸道结果),死亡时间 (生存) 和COVID-19恢复量表 (恢复) 达成共识.
- 建议对其他九个核心结果 (疲劳,疼痛,运动后症状,工作/学习变化,心血管,神经系统,认知,心理健康,身体结果) 的工具,但缺乏共识.
结论:
- 推的COMS提供了评估成年人COVID-19后状况的基础框架.
- 协商一致过程确定了某些长期COVID结果的特定工具,以帮助临床护理和研究.
- 随着长期COVID的新测量仪器的出现,需要对COMS进行进一步评估.
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