儿童的生殖器移植与宿主疾病:一个未经诊断和未经治疗的实体
Kavitha Ganesan1, Suresh Duraisamy1, Satish Kumar Meena1
1Department of Pediatric Hematology, Oncology, Blood and Marrow Transplantation, Apollo Hospitals, Chennai, India.
Transplantation and cellular therapy
|November 5, 2023
概括
生殖器移植对宿主疾病 (GVHD) 影响15.8%的儿科造血干细胞移植接受者. 慢性口腔GVHD强烈预测了生殖器GVHD,需要对儿童进行生殖器检查.
科学领域:
- 儿科血液学/瘤学
- 移植免疫学 移植免疫学
- 移植与宿主疾病研究
背景情况:
- 生殖器移植对宿主疾病 (GVHD) 是小儿血造干细胞移植 (HSCT) 中未被认可的并发症.
- 早期识别和管理对于防止长期后果至关重要.
- 儿童独特的临床特征和风险因素需要特别注意.
研究的目的:
- 报告关于儿科患者GVHD的生殖器表现的数据.
- 描述独特的临床特征,并确定儿童生殖器GVHD的易感因素.
- 突出口腔GVHD和生殖器GVHD之间的关联.
主要方法:
- 从2002年2月到2022年2月,对1035名儿科HSCT接受者 (年龄≤18岁) 的回顾性分析.
- 在164名患者 (15.8%) 中记录了生殖器GVHD.
- 评估了患者的人口统计,调节方案,捐赠者类型,移植来源,性别不匹配以及同时发生的慢性口腔GVHD.
主要成果:
- 生殖器GVHD发生在15.8%的儿科HSCT接受者中.
- 在慢性口服GVHD和生殖器GVHD之间发现了显著的关联 (47.9%的口服GVHD患者有生殖器GVHD).
- 风险因素包括捐赠者和接受者的性别不匹配 (31.1%) 和使用外周血液干细胞 (PBSCs) (78.7%).
- 在21.5%的受影响男孩中,因发炎而需要手术干预.
结论:
- 生殖器GVHD是儿科HSCT的一个重要并发症,通常与慢性口腔GVHD有关.
- 建议对所有为慢性GVHD进行随访的儿童进行常规生殖器检查.
- 捐赠者-接受者性别不匹配和PBSC移植是慢性生殖器GVHD的倾向因素.
相关概念视频
Immunodeficiency Diseases
950
Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency...
There are three main causes of immunodeficiency...
950
Sexually Transmitted Infections
326
Sexually transmitted infections (STIs) are diseases transmitted primarily through unsafe sexual interactions. Bacteria, viruses, or parasites cause them and can result in severe health complications if untreated.ChlamydiaThe bacterium Chlamydia trachomatis is responsible for the disease Chlamydia, the most common STI in the United States. This peculiar pathogen requires human cells to reproduce, residing intracellularly. The initial infection often goes unnoticed because it typically does not...
326
Bone Marrow Sampling and Transplants
339
Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
339
Tissue Transplantation
376
Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
376
Cell-mediated Immune Responses
68.6K
Overview
68.6K
Kidney Transplant I: Introduction
14
A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
14


