在吸烟者和加热烟草产品使用者的代谢学概况改变
Sei Harada1,2, Hideki Ohmomo3, Minako Matsumoto1
1Department of Preventive Medicine and Public Health, Keio University School of Medicine.
Journal of epidemiology
|November 5, 2023
概括
加热烟草制品 (HTP) 的使用改变了血代谢物,特别是在谷氨酸途径中,类似于吸烟. 这表明HTP可能会带来与传统香烟相比的心血管疾病风险.
科学领域:
- 代谢学 代谢学 代谢学
- 心血管疾病研究研究
- 减少烟草的伤害 减少烟草的伤害
背景情况:
- 在全球范围内,加热烟草制品 (HTP) 越来越受欢迎.
- 使用HTP对健康的影响尚未完全理解.
- 评估HTP的健康风险需要确定相关的生物标志物.
研究的目的:
- 为了确定与吸烟和HTP使用相关的血代谢物.
- 为了比较HTP使用者和香烟吸烟者之间的代谢物概况.
- 为了为HTP消费的健康风险评估提供信息.
主要方法:
- 来自大型日本队列 (Tsuruoka Metabolomics队列研究) 的代谢学数据的分析.
- 从9,922名参与者获得的关于吸烟习惯和血代谢物的基线数据.
- 从3334名参与者的随访数据来评估HTP使用者的代谢物变化.
主要成果:
- 与从未吸烟者相比,烟草吸烟者表现出不同的代谢概况,有22个已识别的极性代谢物生物标志物.
- 使用高TP的人的生物标志物概况更像是吸烟者的,而不是从不吸烟者的.
- 在吸烟者和HTP使用者中观察到高谷氨酸水平和相关途径改变,与内皮功能障碍和动脉样硬化有关.
结论:
- 习惯性吸烟显著影响了谷氨酸代谢途径.
- 谷氨酸路径的变化可能部分解释吸烟引起的心血管疾病机制.
- 使用HTP与谷氨酸代谢有关,这表明与吸烟相似的心血管风险.
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