在复发的儿科急性髓性白血病治疗结果和预后因素
Jung Hwan Lee1, Hee Young Ju1, Ju Kyung Hyun1
1Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
Blood research
|November 5, 2023
概括
复发的儿科急性髓性白血病 (AML) 的预后不好. 诸如更长的缓解持续时间,在一次化疗疗程后实现完全缓解 (CR) 和有利的初始诊断等因素改善了AML复发患者的生存结果.
科学领域:
- 儿科瘤学 儿科瘤学
- 血液学 血液学 血液学
- 白血病研究研究 白血病研究
背景情况:
- 儿科急性髓性白血病 (AML) 的结果有所改善,但复发后的预后仍然很差.
- 确定儿科AML复发的预后因素对于改善生存率至关重要.
研究的目的:
- 检查与患有AML第一次复发的儿科患者预后相关的临床因素.
- 确定复发儿科AML的生存预测因素.
主要方法:
- 儿童AML患者第一次复发 (2008-2019) 的回顾性图表审查.
- 基于AML 2012研究标准的诊断风险分层.
- 对影响生存结果的临床因素的分析.
主要成果:
- 总共分析了27名儿科复发性AML患者.
- 五年总生存率 (OS) 和无事件生存率 (EFS) 为32.9%.
- 关键的有利预后因素包括:从诊断到复发的持续时间≥12个月 (5年生存率64.0%),在复发后的一次化疗疗程后实现完全缓解 (CR) (5年生存率59.3%),以及有利/中间初始风险组 (5年生存率62.3%).
结论:
- 在复发之前完全缓解 (CR) 的持续时间较长,在一次再诱导化疗疗程后实现CR,以及有利的初始诊断与复发的儿科AML的更好结果有关.
- 根据复发的预后因素定制治疗策略对于改善儿科AML的结果至关重要.
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