在家族性高胆固醇血症中,对心血管风险的看法存在性别差异
Balaqis Alshibani1, Iulia Iatan2, Amanda Guerin1
1Research Institute of the McGill University Health Centre (Drs Alshibani; Guerin; Ruel; Ramanakumar; Pilote; Genest), Montreal, QC, Canada.
Journal of clinical lipidology
|November 5, 2023
概括
家庭高胆固醇血症 (FH) 患者了解他们的ASCVD风险,但女性更担心高LDL-C和他类药物的安全性. 一般来说,男女对FH的认识都很好.
科学领域:
- 心脏病学 心脏病学
- 遗传学 是一个遗传学.
- 公共卫生 公共卫生
背景情况:
- 家族性高胆固醇血症 (FH) 是一种遗传性疾病,导致高LDL-C和早期心血管疾病.
- 最近的数据表明,女性的FH治疗不足.
- 在FH感知和治疗中的基于性别的差异需要表征.
研究的目的:
- 研究患者如何感知家族性高胆固醇血症 (FH) 的基于性别的差异.
- 为了评估与FH相关的动脉样硬化心血管疾病 (ASCVD) 风险的感知中的基于性别的差异.
- 探索关于FH治疗的理解和担忧的基于性别的差异.
主要方法:
- 采用调查的横截面研究设计.
- 对1073名被诊断患有家族性高胆固醇血症 (FH) 的患者进行了调查.
- 分析了412名患者的反应 (51.9%是男性),以确定性别差异的感知,风险意识和治疗观点.
主要成果:
- 男性的动脉样硬化心血管疾病 (ASCVD) 患病率高于女性 (41.5%vs16.5%).
- 两性都认为他们的ASCVD风险高于健康的同龄人;女性对高的LDL-C水平表示更大的担忧.
- 虽然两种性别都认为他类药物是有效的,但更少的女性认为它们是安全的 (44.8%对男性的60.0%).
结论:
- 患有家族性高胆固醇血症 (FH) 的患者表现出对其病情的良好理解.
- 患有FH的女性对高的LDL-C水平和他类药物的安全性表现出更大的担忧.
- 解决性别特异性问题对于优化FH管理和降低心血管风险至关重要.
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