快速检测胃肠道病原体使用多重聚合酶连锁反应胃肠道面板及其在抗微生物管理中的作用
Chih-Hao Chen1, Yan-Yi Low2, Yu-Hsuan Liu3
1Division of Infectious Diseases, Department of Internal Medicine, China Medical University Hospital, Taichung, Taiwan.
概括
儿童患者在使用FilmArray胃肠道面板 (FAGIP) 时,感染性腹阳性率高于成年人. 这种诊断工具可以减少在急性腹病例中不必要使用抗微生物药物.
科学领域:
- 胃肠病学 胃肠病学
- 传染性疾病 传染性疾病
- 临床诊断 临床诊断 临床诊断
背景情况:
- 电影Array的胃肠道面板 (FAGIP) 在检测传染性腹方面具有很高的灵敏度.
- 病原体分布存在地理差异,影响诊断方法.
研究的目的:
- 为了比较FAGIP的阳性率在患有急性腹的儿童和成人患者中.
- 根据年龄组分析病原体分布和抗菌剂使用情况.
主要方法:
- 在2022年接受FAGIP测试的487名急性腹患者的回顾性分析.
- 在儿科 (n=245) 和成人 (n=242) 队列之间比较FAGIP阳性率,病原体流行率和抗菌剂使用率.
主要成果:
- 与成人 (43.0%) 相比,儿科患者的FAGIP阳性率显著更高 (73.9%).
- 沙门氏菌是儿童中最常见的病原体,而Clostridioides difficile在成人中占主导地位.
- 抗菌剂的使用在FAGIP后下降,在成人中针对C. difficile的向治疗更高.
结论:
- 在急性腹中FAGIP的应用与儿童相比成人的检测率更高有关.
- 使用FAGIP可能会减少对传染性腹的不必要的抗菌素处方.
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