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Updated: Jul 11, 2025

From a Natural Product to Its Biosynthetic Gene Cluster: A Demonstration Using Polyketomycin from Streptomyces diastatochromogenes Tü6028
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在Pyrichalasin H的生物合成过程中从混合PKS-NRPS减少释放

Henrike Heinemann1, Haili Zhang1, Russell J Cox1

  • 1Institute for Organic Chemistry and BMWZ, Leibniz Universität Hannover, Schneiderberg 38, 30167, Hannover, Germany.

Chemistry (Weinheim an der Bergstrasse, Germany)
|November 5, 2023
PubMed
概括

这项研究揭示了混合多基基合成酶-非核糖体合成酶 (PKS-NRPS) 酶复合体是如何启动细胞生物合成的. 这项研究阐明了还原性释放步骤,这对于形成关键分子前体至关重要.

关键词:
特别提款权 (SDR) 是一种特别提款权.赛托哈萨桑是一种细胞质.非核糖体的非核糖体.聚基化物是一种多基化物.减少释放的减缓性释放

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