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制药推进剂的液体电阻使用新型电阻细胞

Hussein Ahmad¹, Manoochehr Rasekh², Nadarajah Manivannan¹

¹College of Engineering, Design and Physical Sciences, Brunel University London, Uxbridge, UB8 3PH, UK.

Scientific reports

|November 5, 2023

概括

这项研究测量了计量剂量吸入器 (MDIs) 中使用的制药推进剂的电阻. 结果显示电阻比之前报告的要高得多,影响了气溶充电和药物输送.

科学领域:

制药科学制药科学
材料科学材料科学材料科学
电气工程电气工程

背景情况:

计量剂量吸入器 (MDIs) 使用推进剂在呼吸系统治疗中产生气溶.
来自MDI的带电气溶可以影响药物沉积在肺部.
精确的推进剂电气性能对于MDI性能和安全至关重要.

研究的目的:

测量主要制药推进剂 (R134a,R152a,R227ea) 在液态相中的直流体积电阻.
研究水分和乙醇对推进剂电阻力的影响.
为MDI开发和监管合规提供可靠的数据.

主要方法:

使用了一种新的,内部设计的同心圆柱式电容电池来进行电阻测量.
在和压力和室温下测量R134a,R152a和R227ea的电阻.
根据IEC 60247标准,测试了不同度的乙醇和水分 (5-500 ppm) 的推进剂混合物.

主要成果:

获得的电阻值是:R134a (3.02 × 10^10 Ωm),R152a (2.37 × 10^9 Ωm),R227ea (1.31 × 10^10 Ωm) 等等.
测量的电阻明显高 (至少两倍) 于之前发布的数据.
阻力因推进剂的组成而异,特别是添加了水分和乙醇.

结论:

该研究为制药推进剂提供了关键的,高精度的电阻数据.
这些发现对于理解和减轻MDIs中的静电效应至关重要.
开发的方法和数据有助于改进MDI设计和性能优化.

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