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心脏和大脑小血管疾病之间的相互关系:试点定量PET和MRI研究

Bianca Mazini¹, Matthieu Dietz^2,3, Bénédicte Maréchal^1,4,5

¹Department of Diagnostic and Interventional Radiology, Neuroradiology Unit, Lausanne University Hospital, Rue du Bugnon 46, CH-1011, Lausanne, Switzerland.

European journal of hybrid imaging

|November 5, 2023

概括

这项研究揭示了心脏和大脑小血管疾病 (SVD) 之间的重要联系,特别影响深灰质. 研究结果表明,SVD可能是一种影响心脏和大脑健康的全身性疾病.

科学领域:

心血管成像和神经学心血管成像
系统性血管疾病研究研究

背景情况:

小血管疾病 (SVD) 与心脏和大脑缺血有关,但其相互关系尚不清楚.
研究心脏和大脑SVD之间的联系对于了解系统性血管健康至关重要.

研究的目的:

评估心脏和大脑小血管疾病 (SVD) 之间的相互关系.
在370名患者中,使用定量82Rb心脏PET/CT和脑MRI使用脑SVD标志物评估心脏SVD标志物.

主要方法:

对370名接受82Rb心脏PET/CT和脑MRI的患者进行了回顾性分析.
通过PET/CT量化左心室心肌动脉血流 (LV-MBF) 和流量储备 (LV-MFR).
评估大脑SVD标志物,包括Fazekas得分,白质病变 (WMab) 容量,深灰质病变 (GMab) 容量,以及使用MRI进行的大脑形态测量.

主要成果:

与正常输液患者相比,患有心脏SVD的患者表现出压力减少的LV-MBF和MFR.
心脏SVD与深灰质的特定变化有关,包括左门,右门和右门的较低z-score.
较低的压力LV-MBF和LV-MFR与左尾状体z-score的降低和右尾状体GMab体积的增加相关.

结论:

在心脏和大脑SVD标志物之间发现了显著的相互关系.
深灰质变化与心脏SVD特别相关,支持SVD作为系统性疾病的假设.

关键词:

冠状动脉疾病是一种冠状动脉疾病.这就是为什么MRI是MRI.形态测量法形态测量法形态测量法在这里,PET是PET.小血管疾病是什么?

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