在基于人口的老年人队列中,神经病变,体力活动和认知功能
Pankaja Desai1, Todd Beck2, Kristin R Krueger2
1Rush Institute for Healthy Aging, Rush University Medical Center, Triangle Office Building, 1700 W Van Buren, Suite 245, Chicago, IL, 60612, USA. pankaja_desai@rush.edu.
BMC geriatrics
|November 5, 2023
概括
身体活动可以减轻神经病症对老年人认知功能的负面影响. 较高的活动水平与更好的认知结果有关,即使在神经病症较高的人群中也是如此.
科学领域:
- 老年学是一门学科.
- 认知神经科学 认知神经科学
- 行为科学 行为科学
背景情况:
- 在老年人群中神经病症,体力活动和认知健康之间的相互作用仍然未被充分探索.
- 了解这些关系对于开发有针对性的干预措施来支持晚年认知功能至关重要.
研究的目的:
- 研究身体活动如何影响神经病症与认知功能和老年人认知衰退之间的关联.
- 检查身体活动在神经病症和各种认知领域之间的关系中所起的适度作用.
主要方法:
- 利用了来自芝加哥健康与衰老项目 (CHAP) 的数据,这是一项基于人口的队列研究.
- 采用混合效应回归模型来分析身体活动,神经病症和认知结果之间的关联.
- 包括7,685名参与者,分析按身体活动水平分层.
主要成果:
- 在基线全球认知功能上发现了高体力活动和神经病症之间具有统计学意义的相互作用.
- 观察到神经病症和高体力活动在基线情节性记忆的相互作用的显著关联.
- 确定了神经病症和高体力活动对随着时间的推移而导致情节性记忆的下降的显著相互作用效应.
结论:
- 发现更高水平的体力活动减少了神经病症和较差的认知结果之间的负面关联.
- 身体活动可以作为一种保护因素,缓冲神经病对衰老认知健康的潜在有害影响.
- 这些发现强调了促进体育活动对于维持老年人认知功能的重要性,特别是那些神经病症较高的人.
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