COVID-19住院患者的血栓炎症反应:一个单一机构的经验
Muhammad Ahmed Sultan1,2, Yvonne Kong1, Chloe Story3
1Department of Haematology, Royal Prince Alfred Hospital, Sydney, New South Wales, Australia.
Internal medicine journal
|November 5, 2023
概括
在1.5年内,COVID-19患者经历了类似的血栓炎症和静脉血栓栓塞 (VTE) 率. 标准的抗凝药和医院管理导致VTE比国际报告更低.
科学领域:
- 传染性疾病 传染性疾病
- 血液学 血液学 血液学
- 关键护理医学 关键护理医学
背景情况:
- 严重的COVID-19与急性炎症和静脉血栓栓塞 (VTE) 的风险增加有关.
- 在COVID-19大流行期间,随着时间的推移,VTE风险的演变仍然不清楚.
- 了解血栓炎症标志物对于管理严重的COVID-19患者至关重要.
研究的目的:
- 在住院COVID-19患者中调查血栓炎症标志物.
- 在这个队列中确定症状性VTE的发病率.
- 评估不同COVID-19变种和流行病浪潮中VTE风险的变化.
主要方法:
- 在皇家阿尔弗雷德王子医院 (2020年3月 - 2021年9月) 住院的205名患者的回顾性队列研究.
- 在祖先,阿尔法和三角洲变种波浪期间包括患者.
- 对凝血试验,炎症标志物 (例如,CRP) 和药物使用的分析.
主要成果:
- 重症监护病房 (ICU) 的患者显示激活的部分血栓形成时间,中性粒细胞数量和C反应蛋白 (CRP) 的增加.
- 94%的患者接受了抗凝药;6.3%的患者出现了静脉血栓炎.
- 与2020年相比,2021年观察到增加抗炎药物使用的趋势.
结论:
- 住院的COVID-19患者表现出与国际数据相比的血栓炎症标志物和VTE率.
- 与同期的全球报告相比,观察到较低的VTE率.
- 控制住院率和遵守抗凝血指南似乎有效地管理COVID-19中VTE风险.
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