探索pH敏感聚合物在向药物输送中的潜力
Shyam Sudhakar Gomte1, Tejas Girish Agnihotri1, Shivani Khopade1
1Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research (NIPER)-Ahmedabad, Palaj, Gandhinagar, Gujarat, India.
Journal of biomaterials science. Polymer edition
|November 6, 2023
概括
对pH敏感的聚合物是针对药物输送 (TDD) 的智能载体,提高了疗效,减少了副作用. 它们与3D打印的结合提供了新的,可控的药物释放系统.
科学领域:
- 聚合物科学 聚合物科学
- 材料科学 材料科学 材料科学
- 制药科学 制药科学
背景情况:
- 对pH敏感的聚合物对于向药物递送 (TDD) 具有至关重要的作用,因为它们对生理pH变化的反应很快.
- 这些智能载体精确地将治疗剂送到目标部位,最大限度地减少非目标释放和减少不良影响.
- 各种pH敏感的聚合物,如基-基-甲基纤维素,Eudragit,聚 (烯酸) 和奇托,在疾病管理方面显示出显著的前景.
研究的目的:
- 系统地审查用于向药物输送的pH敏感聚合物的类型.
- 讨论用于输送这些聚合物的纳米载体.
- 探索pH敏感聚合物的应用,特别是3D打印在先进药物输送系统中的作用.
主要方法:
- 在TDD中对pH敏感聚合物的系统文献综述.
- 讨论用于聚合物输送的纳米载体系统.
- 应用程序的分析,重点是3D打印集成.
主要成果:
- 对pH敏感的聚合物在TDD中显示出增强的治疗效果和降低的毒性.
- 对pH敏感的聚合物与3D打印的整合使得开发可控药物释放的新型系统成为可能.
- 这些聚合物在各种疾病中的多种应用已被确定.
结论:
- 对pH敏感的聚合物对TDD非常有效,提供精确的药物向和减少副作用.
- 对pH敏感的聚合物和3D打印之间的协同作用代表了在开发复杂的药物输送平台方面取得的重大进展.
- 对这些材料和技术的进一步研究有望改善治疗结果.
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