电刺激可以防止在马塞特体缩后的状体和子状体退化
Chuan Wu1, Qunyan Zhang1, Xiuyun Zheng1
1Department of Orthodontics, College & Hospital of Stomatology, Key Laboratory of Oral Diseases Research of Anhui Province, Anhui Medical University, Hefei, China.
Oral diseases
|November 6, 2023
概括
电刺激 (ES) 可以帮助预防由马塞特肌肉缩引起的冠状腺退化. 这项研究发现,ES治疗,特别是7mA/50Hz,显著减少了大鼠骨的骨损失和退化.
科学领域:
- 生物医学工程 生物医学工程
- 再生医学是一种再生医学.
- 矯正牙科 矯正牙科是一種矯正牙科.
背景情况:
- 肌缩与关节 (TMJ) 带退化密切相关.
- 电刺激 (ES) 是一种已知的肌肉缩治疗方法,但它对关节尾的作用尚不清楚.
研究的目的:
- 为了研究ES的潜力,以防止在masseter肌肉缩.
- 评估不同ES参数对状骨健康和相关基因表达的影响.
主要方法:
- 在使用肉毒素 (BTX) 注射的老鼠中诱导了马塞特肌肉缩.
- 鼠被分为对照,BTX-only和BTX + ES组,使用不同的ES参数.
- 微计算机断层扫描 (micro-CT) 和骨质生成,肌体生成和血管生成标志物的基因表达分析在4周后进行.
主要成果:
- 治疗ES,特别是7mA/50Hz,显著降低了masseter肌肉缩.
- ES减弱了冠状腺退化和亚冠状腺骨损失.
- 在ES治疗组中观察到关键蛋白质 (原-1,骨质卡尔辛,BMP2,原2a,VEGF) 的升调.
结论:
- 电刺激在缓解与马塞特肌肉缩相关的状腺退化方面表现有前途.
- 在涉及肌肉缩的条件下,ES可以提供一种治疗策略,以保持关节结构和功能.
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