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脑卒中后远程缺血调节:临床研究中的研究进展

Bin Jiang1, Xiaojie Wang1, Jianping Ma1

  • 1Department of Neurology, Shenzhen Qianhai Shekou Free Trade Zone Hospital, Shenzhen, China.

CNS neuroscience & therapeutics
|November 6, 2023
PubMed
概括

远程缺血调节 (RIC) 为中风治疗提供了一种安全有效的方法. 需要进一步进行大规模研究,以优化RIC协议并了解其机制,以改善中风预防和护理.

关键词:
内动脉样硬化狭窄症缺血/再伤损伤的发生.神经保护神经保护远程缺血性调节的情况.一次性中风中风中风中风中风血管性认知障碍 血管性认知障碍

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科学领域:

  • 神经学 神经学
  • 心血管医学 心血管医学
  • 再生医学是一种再生医学.

背景情况:

  • 脑卒中仍然是一个重大的全球健康挑战,需要创新和可访问的治疗策略.
  • 远程缺血调节 (RIC) 是一种非侵入性,有效的方法,可以增强大脑对缺血损伤的耐受性.
  • RIC已经证明了神经保护作用,包括改善大脑血流和神经再生.

研究的目的:

  • 系统地审查最近关于RIC在中风治疗中的应用的临床研究.
  • 为全面了解RIC在治疗缺血性中风和出血性中风中的作用.

主要方法:

  • 对注册的临床试验进行系统审查,涉及中风患者的RIC.
  • 搜索的主要数据库 (PubMed,科学网,Embase,临床试验.gov) 截至2022年11月.
  • 包括急性缺血性中风,血栓溶解后/血栓切除术,内动脉样硬化,血管认知障碍,莫亚莫亚病和出血性中风的研究.

主要成果:

  • 确定了48项相关研究,其中42项已完成,6项正在进行.
  • 研究涵盖了各种类型的中风和患者群体,包括急性缺血性中风和出血性中风.
  • 在各种中风治疗场景中,RIC证明了安全性和可行性.

结论:

  • 远程缺血调节是一种安全,可行的,有效的中风辅助疗法.
  • 进一步的大规模研究对于确定最佳的RIC协议和阐明潜在机制至关重要.
  • 优化RIC可能会导致中风预防和治疗策略的突破.