减少内内注射相关内炎的发生率,使用预装注射器
Henry L Feng1, Shareif Abdelwahab2, Nareena Imam2
1Illinois Retina Associates, Department of Ophthalmology, Rush University Medical Center, Chicago, IL, USA.
Journal of vitreoretinal diseases
|November 6, 2023
概括
与未预填充的选项相比,用于抗VEGF药物的预填充注射器显著降低了内炎风险. 这一发现凸显了无菌制剂在预防注射后感染方面的重要性.
科学领域:
- 眼科医生 眼科 眼科
- 传染性疾病 传染性疾病
- 药理学 药理学是指药理学的学科.
背景情况:
- 对抗VEGF药物的静脉内注射是治疗视网膜疾病的常见方法.
- 视内膜炎是内内注射后的一种严重并发症.
- 反VEGF药物的制备方法可能会影响感染风险.
研究的目的:
- 为了比较预填注射器和非预填注射器中的抗VEGF药物之间的内炎发病率.
- 分析注射相关内炎的临床特征和结果.
主要方法:
- 在2014年1月1日至2019年12月31日期间注射的静脉内抗VEGF注射的回顾性图表审查.
- 鉴定和分析被诊断为注射相关内炎的眼睛.
- 基于药物类型 (预填与非预填) 的内炎率和微生物发现的比较.
主要成果:
- 总共有325,990次注射被审查,其中88例是内炎的病例.
- 拉尼比祖马布预填注射器 (RANPFS) 的内炎发病率最低,为0.0154%,相比之下,贝瓦西祖马布 (0.0312%),拉尼比祖马布 (0.0226%) 和阿弗利伯塞普 (0.0366%).
- RANPFS显示了显著较低的培养证明内眼炎率 (P = .003),视力敏度结果在各组中相似.
结论:
- 预装注射器中的抗VEGF药物可能会降低在制备过程中药物污染的风险.
- 与未预填充的抗VEGF药物相比,Ranibizumab预填充注射器 (RANPFS) 与注射相关的内炎的发病率较低.
- 预填注射器代表了一种潜在的更安全的选择,用于静脉内抗VEGF的管理.
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