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与MEK和纤维细胞生长因子受体抑制剂组合相关的血清性视网膜病变

H Russell Day¹, Avni P Finn¹

¹Vanderbilt Eye Institute, Vanderbilt University Medical Center, Nashville, TN, USA.

Journal of vitreoretinal diseases

|November 6, 2023

概括

化学疗法结合纤维细胞生长因子受体 (FGFR) 和基因激活蛋白激酶 (MEK) 抑制剂导致血清性视网膜病变. 这种组合治疗可能会增加视网膜毒性的风险和严重程度.

科学领域:

在瘤学瘤学.
眼科医生眼科眼科
药理学药理学是指药理学的学科.

背景情况:

癌症疗法越来越多地使用有针对性的药物.
纤维细胞生长因子受体 (FGFR) 和基激活蛋白激酶 (MEK) 抑制剂用于癌症治疗.
了解药物诱导的眼部毒性对于患者管理至关重要.

研究的目的:

报告一种血清性视网膜病变的病例.
为了研究与FGFR和MEK抑制剂联合治疗方案相关的眼睛毒性.

主要方法:

一个单一患者病例的回顾性图表审查.
临床表现和治疗方案的分析.

主要成果:

一名67岁的胰腺癌和前列腺癌男性患者出现了双边多焦点下液.
眼部不良事件发生在试验性化疗疗法治疗期间,该疗法结合了特拉美丁尼布 (MEK 抑制剂) 和厄尔达菲提尼布 (FGFR 抑制剂).

结论:

联合FGFR和MEK抑制可能导致视网膜毒性增加和潜在的严重毒性.
相对于MEK通路,FGFR的上游位置可能会增强眼部的副作用.
需要进行进一步的研究,以制定接受这种组合治疗的患者眼科监测指南.

关键词:

这是一种MEK抑制剂.纤维细胞生长因子受体抑制剂视网膜毒性视网膜毒性血性视网膜病变是一种血性视网膜病变.

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