根据深静脉血栓形成的局部位置的D-Dimer和纤维素原值
Akif Mlačo1, Nejra Mlačo2, Edin Begić3
1Department of Angiology, Clinic for Heart, Blood Vessel and Rheumatic Diseases, Clinical Center University of Sarajevo, Sarajevo, Bosnia and Herzegovina.
概括
在大多数静脉血栓栓塞 (VTE) 病例中,D-二聚和纤维素水平升高. 较高的水平与骨上垂体深静脉血栓形成 (DVT) 相相关,但仅靠这些生物标志物就无法精确确定血栓形成的位置.
科学领域:
- 血管医学 血管医学
- 诊断生物标志物 诊断生物标志物
- 血栓形成研究研究
背景情况:
- D-二聚和纤维素原已确立,但是静脉血栓塞栓症 (VTE) 的非特异性标志物.
- 了解它们与深静脉血栓症 (DVT) 解剖学定位的关系对于诊断至关重要.
- 以前的研究并没有完全阐明这些相关性.
研究的目的:
- 调查D-二聚和纤维素水平之间的关联以及深静脉血栓症 (DVT) 的解剖位置.
- 确定这些生物标志物是否能够区分各种DVT位置.
- 提供对复杂静脉瘤病例中D-二聚合物和纤维素原的诊断实用性的见解.
主要方法:
- 观察性研究包括1,142名住院患者 (2010-2019).
- 收集的数据包括患者人口统计数据,血栓的位置 (骨髓上,骨髓上和骨上,小腿,上肢),D-二次体和纤维素素水平.
- 统计分析以比较不同DVT位置的生物标志物值.
主要成果:
- 在89.6%和67.3%的患者中,分别观察到升高的D-二聚物 (>0.55 mg/L) 和纤维素素 (>3.8 g/L).
- 在患有 iliofemoral DVT 的患者中发现了最高的平均 D-二聚合物 (10.48 mg/L) 和纤维素原 (4.87 g/L) 水平.
- 生物标志物水平明显高于 iliofemoral DVT 与大腿-popliteal 和小腿DVT相比; D-二次数在下肢DVT高于上肢DVT.
结论:
- 在 iliofemoral DVT 中,D-二聚合物和纤维素水平显著升高.
- 虽然这些生物标志物表明了血栓形成的严重程度和位置,但这些生物标志物不足以准确地对DVT进行解剖学歧视.
- 进一步的成像研究仍然对于准确诊断和深静脉血栓的局部化至关重要.
相关概念视频
01:20Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies
12
The key difference between Superficial Vein Thrombosis (SVT) and Deep Vein Thrombosis (DVT) lies in their location and severity.Clinical ManifestationsSVT typically presents with localized pain, tenderness, and redness along the course of a superficial vein, often accompanied by a palpable, cord-like structure under the skin. This condition is usually less dangerous than DVT but can be uncomfortable and may lead to complications such as cellulitis or, rarely, a clot extension into the deep...
12
01:30Venous Thrombosis I: Introduction
11
Venous thrombosis, the most common disorder of the veins, involves the formation of a thrombus or blood clot associated with vein inflammation. It can be classified as either superficial vein thrombosis or deep vein thrombosis.Superficial Vein Thrombosis: This involves the formation of a thrombus in a superficial vein, usually the greater or lesser saphenous vein. Though less severe than deep vein thrombosis (DVT), SVT can lead to complications if untreated.Deep Vein Thrombosis (DVT): This...
11
01:29Venous Thrombosis III: Interprofessional Care
10
Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...
10
01:30Venous Thrombosis IV: Nursing Management
14
Nursing management begins with a thorough assessment of the patient's health history. Key factors include trauma to veins, peripherally inserted central catheters, varicose veins, recent pregnancy or childbirth, surgery, bacteremia, prolonged bed rest, atrial fibrillation, COPD, heart failure, cancer, coagulation disorders, myocardial infarction, spinal cord injury, stroke, prolonged travel, recent bone fractures, and dehydration. Review medication intake, particularly oral contraceptives,...
14
01:30Anticoagulant Drugs: Low-Molecular-Weight Heparins
719
Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
719
01:27Pulmonary Embolism III: Nursing Management
15
A pulmonary embolism occurs when a thrombus, amniotic fluid, tumor tissue, fat, or air embolus blocks one or more pulmonary arteries. Effective nursing management and patient education are crucial for improving outcomes and preventing recurrence.Nursing management starts with obtaining a comprehensive patient history, particularly noting any history of deep vein thrombosis (DVT). Assess for clinical manifestations, including dyspnea, chest pain, crackles, heart murmurs, and signs of right-sided...
15