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用于再生疗法的脱细胞化细胞外矩阵生物材料:进展,挑战和临床前景
Aleksandra A Golebiowska1, Jonathon T Intravaia1, Vinayak M Sathe2
1Department of Biomedical Engineering, University of Connecticut, Storrs, CT, 06269, USA.
Bioactive materials
|November 6, 2023
概括
脱细胞化细胞外基质 (dECM) 生物材料通过模仿本地组织环境,对组织工程具有前景. 需要进一步的研究来优化dECM,以提高再生疗法和临床转化.
科学领域:
- 生物材料科学 生物材料科学
- 再生医学是一种再生医学.
- 组织工程是组织工程.
背景情况:
- 目前的组织工程支架努力复制本地微环境,以实现最佳的组织再生.
- 脱细胞化组织和细胞衍生的细胞外基质 (dECM) 提供生物相容和生物活性替代品.
研究的目的:
- 审查dECM生物材料和生物墨水在组织工程和再生医学中的新兴前沿.
- 突出dECM在为增强细胞调节和修复创造组织特异性微环境方面的潜力.
主要方法:
- 对脱细胞化组织衍生和细胞衍生生物材料和生物墨水的审查.
- 讨论脱细胞化技术及其对dECM特性的影响.
- 探索dECM在刺激in situ组织修复中的作用.
主要成果:
- dECM生物材料可以被设计成模仿本地组织结构和组成的多孔支架.
- 生物活性dECM提供了特定于组织的微环境来指导细胞过程.
- dECM显示出无细胞,基于生长因子的组织工程策略的潜力.
结论:
- 优化脱细胞化方法至关重要,以保持dECM的原生特性,以有效地进行组织仿真.
- dECM生物材料具有刺激局部组织修复的巨大潜力.
- 解决绝育,保存和临床翻译方面的挑战是基于dECM的治疗方法的关键.
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