炎症和凝血是两种相互关联的病理生理路径在心房的发病性病原体
Lusine Hazarapetyan1,2, Parounak H Zelveian2, Svetlana Grigoryan1,2
1Department of Cardiology, Yerevan State Medical University Named After M. Heratsi, Yerevan, Armenia.
Journal of inflammation research
|November 6, 2023
概括
心房动 (AF) 患者表现出较高的炎症和凝固因子. 这些标记与心脏结构变化相关,表明AF中炎症,凝血和心房重塑之间存在联系.
科学领域:
- 心脏病学 心脏病学
- 生物化学 生物化学
- 病理生理学 病理生理学
背景情况:
- 心房动 (AF) 与组织因子 (TF) 和XII因子 (FXII) 等凝血因子的增加有关.
- 炎症标志物升高,包括互白素-6 (IL-6),瘤亡因子-α (TNF-α) 和高敏感性C反应蛋白 (hs-CRP),也与AF有关.
研究的目的:
- 调查非膜性AF患者的炎症标志物和凝血活动之间的关系.
- 探索这些标记物对心脏结构变化的影响,特别是心房重塑.
主要方法:
- 研究了283名患有非膜AF的患者和对照组.
- 使用ELISA测量凝血和炎症标志物.
- 使用SPSS统计软件分析数据.
主要成果:
- 与对照组相比,AF患者的hs-CRP,IL-6,TNF-α,TF和FXII水平显著更高.
- 在IL-6和左心脏直径/硬度之间,以及hs-CRP/TF和左心脏体积之间发现了中等相关性.
结论:
- 患有AF的患者显示,炎症标志物升高与凝血活动之间存在关联.
- 这种相互作用有助于AF患者的结构性心房重塑.
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