早期生活压力和精神分裂症对运动和认知功能的影响:一项实验性研究
Fredrick Otieno Oginga1, Thabisile Mpofana1,2
1Department of Physiology, School of Laboratory Medicine and Medical Sciences, University of Kwa-Zulu Natal, Durban, South Africa.
Frontiers in integrative neuroscience
|November 6, 2023
概括
早期生活压力和父母精神分裂症显著增加了类似焦虑的行为,并损害了老鼠的空间记忆. 积极的育儿可以扭转这些负面的神经生物学影响中的一些.
科学领域:
- 神经科学是一个神经科学.
- 行为科学 行为科学
- 精神病学是一个精神病学.
背景情况:
- 早期生活压力 (ELS) 和父母的精神病理学,如精神分裂症,与长期的神经生物学和行为变化有关.
- 现实世界的压力因素往往同时发生,需要研究它们的综合影响.
研究的目的:
- 研究ELS和精神分裂症对Sprague Dawley大鼠的运动活动,焦虑,探索行为和空间记忆的影响.
- 了解ELS和家长精神病理学结合的互动影响.
主要方法:
- 鼠被分配到对照,ELS,精神分裂症或ELS +精神分裂症组合.
- 通过产前压力和母亲分离诱导ELS;使用胺激素诱导精神分裂症.
- 行为评估包括开放场地和莫里斯水迷宫测试;使用ANOVA分析的数据.
主要成果:
- ELS和父母的精神病理加剧了精神分裂症症状,特别是精神运动迟缓.
- 无论是ELS还是家长精神病理,都增加了类似焦虑的行为,组合组显示的最高水平.
- 在ELS和组合组中,空间记忆受到损害;ELS减少了GFAP+天体细胞,这种效应被积极的育儿扭转.
结论:
- ELS和家长精神病理学相互作用,影响类似焦虑的行为和空间记忆.
- ELS增加了焦虑,而精神分裂症与无情感有关.
- 积极的育儿可以增强神经可塑性,突触功能和认知能力.
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