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lncRNA H19的rs217727与中国汉族人口的宫癌风险有关

Jie Dai¹, Shao Zhang², Yuhan Shi³

¹Department of Immunogenetics, Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Kunming, 650118, People's Republic of China.

Pharmacogenomics and personalized medicine

|November 6, 2023

概括

长非编码RNA H19 中的单核酸多态性与中国汉族人口的宫癌风险有关. 具体来说,rs217727-A等位基因增加了对子宫状细胞癌的易感性.

科学领域:

遗传学是一个遗传学.
在瘤学瘤学.
分子生物学分子生物学

背景情况:

长非编码RNAs (LncRNAs) 在宫癌 (CC) 的发展中发挥作用.
研究lncRNAs的遗传变异可以确定癌症风险因素.
特定的lncRNAs如H19,HOTAIR,HOTTIP和CASC8都与CC病变发生有关.

研究的目的:

探索关键 lncRNA 中单核酸多态 (SNP) 与患子宫癌的风险之间的关联.
评估H19,HOTAIR,HOTTIP和CASC8基因中的特定SNP (rs217727,rs2366152,rs1859168,rs10505477) 对CC敏感性的影响.
分析中国汉族人口中的关联.

主要方法:

使用MassArray进行了四个选定的SNP (rs217727,rs2366152,rs1859168,rs10505477) 的基因型识别.
研究包括1426名参与者:274名CIN患者,448名CC患者和704名健康对照.
统计分析以评估SNP与CC风险之间的关联.

主要成果:

rs217727的基因分布显示了CC患者和对照人群之间的显著差异 (P=0.001).
rs217727-A基因组与CC的风险增加有关 (OR=1.33).
rs217727的A/A基因型被确定为CC的风险因素 (P=0.001,OR=1.35),特别是宫平细胞癌 (SCC) 的风险因素 (P=0.002,OR=1.33).

结论:

在lncRNA H19基因中的SNP rs217727与子宫癌易感性显著相关.
确定rs217727-A等位基因和A/A基因型是CC的风险因素,特别是SCC.
这一发现突显了lncRNAs中的遗传变异作为CC风险的潜在生物标志物的作用.

关键词:

这是CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC H19 H19 是一种H19病毒.国家统一计划 (SNP) 是一个国家统一计划.协会协会协会协会协会宫癌:子宫癌是一种癌症.在cnRNA中.长非编码RNAs的编码.

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