诊断上不一致的Clostridioides difficile临床标本的患病率:从纵向监测中的见解
Farhan Anwar1, Marielle Clark1, Jason Lindsey1
1School of Animal and Comparative Biomedical Sciences, University of Arizona, Tucson, AZ, United States.
Frontiers in medicine
|November 6, 2023
概括
许多Clostridioides difficile感染 (CDI) 测试对毒素呈阴性,但对细菌呈阳性. 这项研究在69%的毒素负样本中发现有毒的C. difficile,突出了潜在的错过诊断.
科学领域:
- 临床微生物学 临床微生物学
- 传染性疾病 传染性疾病
- 胃肠病学 胃肠病学
背景情况:
- 困难闭膜炎感染 (CDI) 是一个重要的与医疗保健相关的腹疾病.
- 当前的诊断经常错过感染,当毒素测试是负面的,尽管有病原体的存在.
研究的目的:
- 为了确定毒素阴性 (异形) CDI标本的频率.
- 分析这些不一致的标本中C. difficile菌株的多样性.
主要方法:
- 在8年的时间里 (2015-2022年) 对腹性便标本进行了纵向监测.
- 对C. difficile及其毒素进行酶免疫测试 (EIA).
- 在C. difficile分离物中进行DNA指纹 (核型) 检测.
- 在选择的隔离物中量化毒素的产生.
主要成果:
- 19.4%的标本含有C. difficile;流行率和多样性保持稳定.
- 在69%的毒素阴性标本中发现有毒的C. difficile.
- 在毒素负样本中,普遍存在的美国核型是常见的,产生的毒素比预期的少.
结论:
- 毒素EIA阴性标本经常含有有毒性C. difficile.
- 很大一部分不一致的结果涉及已知的毒性菌株.
- 重新评估不一致的CDI测试结果对于避免错过诊断和了解C. difficile持久性至关重要.
关键词:
克洛斯特里迪奥伊德斯困难菌不一致的不一致的在纵向的长度上.患病率的流行情况.带型化 (ribotyping) 是指对一个物体进行带型化.监控监督监督监督监督监督监督监督监督监督监督监督监督监督监督监督监督监督更多相关视频
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