升高的矩阵金属蛋白酶-9表达与COVID-19严重程度有关:一个元分析
Ling Ding1,2, Haipeng Guo1,2, Chao Zhang1,2
1Department of Laboratory Medicine, The First Hospital of Qiqihar, Qiqihar, Heilongjiang 161005, P.R. China.
Experimental and therapeutic medicine
|November 6, 2023
概括
血清矩阵金属蛋白酶-9 (MMP-9) 水平在严重的COVID-19病例中升高,并与ARDS等并发症相关. 较高的MMP-9表明COVID-19患者的疾病严重程度增加和潜在的治疗目标.
科学领域:
- 生物化学 生物化学
- 免疫学 免疫学 免疫学
- 传染性疾病 传染性疾病
背景情况:
- 新型冠状病毒疾病2019 (COVID-19) 给全球健康带来了重大挑战.
- 了解COVID-19严重程度的生物标志物对于患者管理至关重要.
- 矩阵金属蛋白酶-9 (MMP-9) 与炎症过程有关.
研究的目的:
- 评估COVID-19患者血清MMP-9水平的临床意义.
- 为了将MMP-9水平与疾病严重程度和患者结果相关联.
主要方法:
- 对12项涉及2062名COVID-19患者的研究进行了元分析.
- 搜索了包括PubMed,科学网,EMBASE,Cochrane,WANFANG和CNKI在内的数据库.
- 在不同患者亚组中比较血清MMP-9水平 (严重与非严重,ARDS与非ARDS,幸存者与非幸存者等). ) 的情况.
主要成果:
- 在严重的COVID-19患者中,血清MMP-9水平明显高于非严重病例.
- 在急性呼吸窘迫综合征 (ARDS) 患者中观察到MMP-9水平升高.
- 在患有神经综合征和肥胖糖尿病患者中也发现了更高的MMP-9水平.
结论:
- 血清MMP-9水平与COVID-19的严重程度有显著的关联.
- MMP-9可能作为预测COVID-19进展的潜在生物标志物.
- 准MMP-9可能是改善COVID-19患者预后的治疗策略.
相关概念视频
01:23Role of Matrix Metalloproteases in Degradation of ECM
2.4K
Matrix metalloproteases (MMPs) are enzymes involved in the hydrolysis of proteins and glycoproteins of the extracellular matrix. MMPs are essential for the migration and proliferation of cells through the dense matrix network, throughout embryonic development, and throughout morphogenesis. The first MMP activity discovered was a collagenase in a tadpole's tail undergoing metamorphosis. The active collagen deposition and modifications lead to the morphogenesis of tadpoles into the adult...
2.4K
01:26Extracellular Matrix
2.9K
Unlike epithelial tissue, which is composed of cells closely packed with little or no extracellular space in between, connective tissue cells are dispersed in a matrix. This extracellular matrix (ECM) is composed of fibrous proteins like collagen, elastin, and fibronectin in a ground substance consisting of interstitial fluid, cell adhesion proteins, and proteoglycans. The proteoglycans form a gel-like material in the spaces between cells and provide hydration, buffering, binding, and force...
2.9K
01:29The Extracellular Matrix
9.0K
Overview
In order to maintain tissue organization, many animal cells are surrounded by structural molecules that make up the extracellular matrix (ECM). Together, the molecules in the ECM maintain the structural integrity of tissue as well as the remarkable specific properties of certain tissues.
Composition of the Extracellular Matrix
The extracellular matrix (ECM) is commonly composed of ground substance, a gel-like fluid, fibrous components, and many structurally and functionally diverse...
In order to maintain tissue organization, many animal cells are surrounded by structural molecules that make up the extracellular matrix (ECM). Together, the molecules in the ECM maintain the structural integrity of tissue as well as the remarkable specific properties of certain tissues.
Composition of the Extracellular Matrix
The extracellular matrix (ECM) is commonly composed of ground substance, a gel-like fluid, fibrous components, and many structurally and functionally diverse...
9.0K
01:24Overview of Cell-Matrix Interactions
7.2K
The extracellular matrix or ECM holds cells together to form a tissue and allows the cells within the tissue to communicate. ECM comprises proteins such as fibronectin, collagen, laminin, etc. The most abundant protein in this space is collagen. Collagen fibers are interwoven with carbohydrate-containing protein molecules called proteoglycans. ECM allows cell migration and provides a structural scaffold at cell adhesion that anchors the cell when the extracellular matrix proteins interact with...
7.2K