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癌症免疫治疗的组合阻断:针对新兴的免疫检查点受体
Dia Roy1, Cassandra Gilmour1,2, Sachin Patnaik1
1Department of Translational Hematology and Oncology Research, Cleveland Clinic Foundation, Cleveland, OH, United States.
Frontiers in immunology
|November 6, 2023
概括
针对PD-1和CTLA-4等共抑制受体的免疫检查点抑制剂 (ICI) 在癌症免疫治疗中至关重要. 本综述探讨了新兴的免疫检查点受体 (ICR) 和组合策略,以增强抗瘤免疫力.
科学领域:
- 免疫学 免疫学 免疫学
- 在瘤学瘤学.
- 癌症免疫疗法癌症免疫疗法
背景情况:
- 瘤特异性CD8+细胞毒性T细胞对于抗瘤免疫至关重要,但由于免疫抑制性瘤微环境,它们往往变得功能障碍.
- 共同抑制受体,包括PD-1,CTLA-4,VISTA,TIGIT,TIM-3和LAG-3,共同称为免疫检查点受体 (ICR),损害T细胞功能,并导致免疫逃避.
- 针对这些ICR的免疫检查点抑制剂 (ICI) 已经彻底改变了癌症治疗,为各种癌症提供了新的希望.
研究的目的:
- 审查VISTA,TIGIT,TIM-3和LAG-3等新兴ICR的机制.
- 总结支持组合免疫疗法策略的临床前和临床数据.
- 突出结合不同ICI疗法的潜力,以改善患者的治疗结果.
主要方法:
- 临床前研究和临床试验的文献综述.
- 通过各种ICR介导的分子通路的分析.
- 对新出现的ICR及其在抗瘤免疫力中的作用的综合数据.
主要成果:
- 新兴的ICR如VISTA,TIGIT,TIM-3和LAG-3在调节T细胞反应方面发挥着重要作用.
- 涉及多个ICI的组合策略显示出协同治疗效益的希望.
- 通过针对额外的共抑制途径,可以改进现有的ICI疗法.
结论:
- 了解ICR的多样化机制对于开发有效的癌症免疫疗法至关重要.
- 针对多个免疫检查点的组合方法具有克服治疗耐药性和改善患者反应的巨大潜力.
- 对新兴ICR及其与现有疗法的结合进行进一步的研究是有必要的,以推进癌症免疫疗法.
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