性结肠炎或克罗恩病患者的直肠急症:来自全球调查的分析
Christina Ha1, April N Naegeli2, Rina Lukanova3
1The F. Widjaja Foundation Inflammatory Bowel Immunology Research Institute at Cedars-Sinai, Los Angeles, CA, USA.
Crohn's & colitis 360
|November 6, 2023
概括
结直肠急性是炎症性肠病 (IBD) 的常见症状,与性结肠炎 (UC) 和克罗恩氏病的增加疾病活性和降低生活质量有关.
科学领域:
- 胃肠病学 胃肠病学
- 炎症性肠病 (IBD) 研究研究
- 患者报告的结果 (PROs)
背景情况:
- 直肠急性是炎症性肠病 (IBD) 中报告不足的症状.
- 它的患病率和与疾病活动和患者结果的关联需要现实世界的调查.
研究的目的:
- 评估性结肠炎 (UC) 和克罗恩病 (CD) 患者的直肠急症的患病率.
- 确定直肠急症与疾病活动以及患者报告的结果 (PROs) 之间的关联.
主要方法:
- 一个多中心,时间点调查胃肠科医生和UC或CD的成年患者.
- 数据收集自2017-2018年阿德尔菲IBD疾病特定计划TM在六个国家.
- 在患有和没有直肠急症的患者之间比较人口统计,临床特征,疾病活性,症状和PROs.
主要成果:
- 20.2%的UC患者和16.4%的CD患者报告了直肠急症.
- 患有直肠急症的患者表现出明显更高的疾病活性 (中度/严重疾病,更高的梅奥/CDAI得分).
- 直肠急性与较低的生活质量 (较低的Short IBDQ分数) 和增加的工作障碍有关.
结论:
- 结直肠急性是IBD中普遍存在的症状,与疾病活性升高和生活质量下降相关.
- 建议在临床实践中定期评估直肠急症,以更好地评估UC和CD患者的疾病活性.
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