人类瘤病毒:诱导宿主基因组结构中的三维改变
1Department of Oral Biology and Experimental Dental Research, Faculty of Dentistry, University of Szeged, Szeged, Hungary.
Frontiers in microbiology
|November 6, 2023
概括
瘤病毒改变宿主细胞基因表达和3D基因组结构,导致不受控制的增殖和癌症. 本综述探讨了像HTLV-1,HPV,EBV,HBV和HCV这样的病毒如何通过基因组相互作用和染色质变化对瘤发生产生贡献.
科学领域:
- 病毒学 病毒学
- 在瘤学瘤学.
- 基因组学就是基因组学.
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
背景情况:
- 瘤病毒 (瘤病毒) 可以改变细胞,导致不受控制的增殖和恶性瘤.
- 七种人类病毒被认为是人类恶性瘤的致病原体.
- 病毒瘤蛋白和RNAs影响宿主基因表达,并诱导遗传/表观遗传变化.
研究的目的:
- 审查了解瘤病毒如何与3D宿主基因组结构相互作用和改变的最新进展.
- 要突出与染色质变化相关的病毒诱导瘤发生的机制.
主要方法:
- 综述使用染色体构造捕获技术的研究.
- 分析3D分子成像技术,研究病毒与宿主基因组相互作用.
- 关于病毒DNA整合和与宿主染色体的环节性基因组相互作用的发现的总结.
主要成果:
- 人类T细胞淋巴细胞病毒1型 (HTLV-1) 插入CTCF结合部位有助于淋巴发生.
- 高风险的人类乳头瘤病毒的整合促进了宫癌的产生.
- 讨论了爱斯坦-巴尔病毒 (EBV),乙型肝炎病毒 (HBV) 和型肝炎病毒 (HCV) 与宿主染色质的相互作用,包括RNA病毒诱导的转化机制.
结论:
- 瘤病毒采用各种策略来操纵宿主细胞的3D基因组结构和基因表达,从而推动瘤发生.
- 了解这些病毒宿主基因组相互作用对于破译癌症发展和确定治疗点至关重要.
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