在无症状的2型糖尿病中,通过跑步机运动应激回声心脏学检测到异常的左心室缩储备功能
Yuyou Duan1, Luwei Ye2, Qinglan Shu2
1School of Clinical Medicine, Southwest Medical University, Luzhou, China.
Frontiers in cardiovascular medicine
|November 6, 2023
概括
亚临床左心室 (LV) 缩功能障碍在无症状2型糖尿病 (T2DM) 患者中受损,尽管缩储量正常. 高HbA1c,NTproBNP,hsCRP和腰围预测这种损伤.
科学领域:
- 心脏病学 心脏病学
- 糖尿病学 糖尿病学
- 心声回声扫描 (Echocardiography) 是一种心声回声扫描.
背景情况:
- 亚临床左心室 (LV) 功能障碍可以发生在无症状的2型糖尿病患者中.
- LV 储备功能是早期,微妙的 LV 功能障碍的敏感指标.
研究的目的:
- 评估无症状T2DM患者的LV储备功能,使用跑步机运动应激心声学 (ESE).
- 探索T2DM中血清生物参数和LV储备功能的关系.
主要方法:
- 84名无症状T2DM患者和41名健康对照人接受了跑步机ESE.
- 静脉缩 (GLS,SRs) 和腹缩 (E,e',E/e',SRe,SRa) 参数在休息和运动后进行测量.
- 计算了LV储备功能的运动后和休息值之间的差异;分析了与血清标志物的关联.
主要成果:
- 根据GLS和SRs的变化表明,LV缩储备在T2DM患者中与对照组相比显著较低 (P < 0.001).
- 在T2DM患者和对照人群中,LV腹痛储备的测量没有显著差异.
- 糖化血红蛋白 (HbA1c),NT-proBNP,hsCRP和腰围是 LV 缩储备受损的独立预测因素.
结论:
- 无症状的T2DM患者表现出 LV 缩储备功能受损,而腹缩储备仍然保持.
- 升高的HbA1c,NT-proBNP,hsCRP和增加的腰围独立地与T2DM中减少的LV缩储量有关.
- 这些发现凸显了ESE在T2DM早期心脏功能障碍检测方面的实用性,并确定了风险分层的关键预测因素.
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