面膜腹侧髓中的腺素A2A受体参与了高血压大鼠的电 ?? 疗法降低血压
Zhi-Ling Guo1, Stephanie C Tjen-A-Looi1, Anh Thingoc Nguyen1
1Susan-Samueli Integrative Health Institute and Department of Medicine, College of Health Sciences, University of California, Irvine, CA, United States.
Frontiers in cardiovascular medicine
|November 6, 2023
概括
电针 (EA) 通过激活大脑干中的腺A2A受体 (A2AR) 来降低大鼠的高血压. 这项研究表明,在高血压大鼠中,经过四周的EA治疗,通过这种特定机制降低了血压.
科学领域:
- 心血管生理学心血管生理学
- 神经科学是一个神经科学.
- 补充医学是一种补充医学.
背景情况:
- 针是一种广泛使用的补充疗法,用于管理高血压 (BP).
- 针降低血压的确切机制,特别是持续高血压,尚未完全理解.
- 之前的研究表明,在电针 (EA) 的急性血压降低作用中,面腹侧髓 (rVLM) 中的腺A2A受体 (A2AR) 有作用.
研究的目的:
- 调查在rVLM中A2AR的激活是否有助于高血压大鼠EA治疗过程中持续降低血压的影响.
- 为了确定一个为期四周的EA疗法是否能调节对盐敏感的高血压大鼠的rVLM中的A2AR表达或功能.
主要方法:
- 达尔盐敏感高血压大鼠 (DSHRs) 接受了EA (每周两次) 或假EA的四周治疗方案.
- 评估了EA对BP的影响,随后通过微注射检查了rVLM A2AR的作用,使用A2AR抗剂 (SCH 58261) 和激动剂 (CGS-21680).
- 在rVLM中的A2AR水平在治疗期后使用西斑分析量化.
主要成果:
- 在DSHR中,EA治疗显著降低了血压,这种效果在假EA或没有针时没有观察到.
- 在rVLM中,EA的降血压效应被A2AR抗剂SCH 58261消除,但不是车辆.
- 将A2AR激动剂CGS-21680微注射到rVLM中,在假EA治疗的老鼠中降低了血压,并且与对照组相比,EA治疗后rVLM中的A2AR水平升高.
结论:
- 一个为期四周的EA治疗疗程有效降低了对盐敏感的高血压大鼠的血压.
- 这些发现强烈表明,EA的持续低血压效应至少部分通过在面腹侧髓内激活氨酸A2AR来调解.
- 这项研究阐明了一条关键的神经化学途径,涉及针对高血压的治疗效果.
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