酸盐治疗的逻辑是调节肠道微生物群,并防止与手术相关的感染
1Sarah and Harold Lincoln Thompson Professor of Surgery University of Chicago, 5841 S Maryland MC 6090, Chicago, Illinois 60637.
Microbiota and host
|November 6, 2023
概括
手术部位感染 (SSIs) 可能来自患者自己的细菌,而不是外部污染. 通过向治疗来保护肠道健康可能比广泛的抗生素更有效地预防手术后感染.
科学领域:
- 传染性疾病 传染性疾病
- 手术部位感染 (SSI) 是一种手术部位感染.
- 微生物组研究 微生物组研究
背景情况:
- 术后感染或手术部位感染 (SSI) 仍然是一个挑战,尽管感染控制和抗生素使用方面取得了进展.
- 目前的战略往往侧重于外部污染,主张预防性抗生素和严格无菌.
- 从表面到深层的器官空间感染,严重的病例导致败血症和死亡.
研究的目的:
- 提出一个关于术后感染和手术部位感染 (SSI) 起源的替代观点.
- 质疑普遍认为SSI主要来自外部污染的观点.
- 探索内源性病原体和肠道生态在SSI中的作用.
主要方法:
- 审查目前的感染控制和手术中的抗生素预防实践.
- 手术部位感染 (SSI) 的内源与外源源的概念审查.
- 讨论肠道生态对术后感染发展的影响.
主要成果:
- 提出许多手术后感染和SSI可能源于患者的内源性病原体,特别是在现代无菌协议的背景下.
- 质疑在选择性外科手术中广泛使用抗生素的进化稳定性和必要性.
- 强调肠道微生物组破坏对SSI发展的潜在影响.
结论:
- 表明内源性病原体在术后感染和手术部位感染 (SSI) 中起着重要作用.
- 倡导保护肠道微生物群的策略,并减弱病原体毒性,而不是使用广谱抗生素.
- 呼吁重新评估目前预防SSI的方法,考虑肠道生态.
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