胆囊切除术与骨质疏松症风险的关联:使用英国生物银行数据的前性研究
Qin Yang1, Ming Wang1, Tongtong Zhang2
1Section for HepatoPancreatoBiliary Surgery, Department of General Surgery, The Third People's Hospital of Chengdu and The Affiliated Hospital of Southwest Jiaotong University, Chengdu, China.
Frontiers in endocrinology
|November 6, 2023
概括
之前的胆囊切除术增加了男性和女性骨质疏松症的风险. 这项研究强调了需要提高对胆囊切除手术病史患者骨质疏松症的认识.
科学领域:
- 骨代谢和内分泌学 骨代谢和内分泌学
- 手术结果和患者健康状况
背景情况:
- 胆囊切除术,胆囊切除,可能会影响代谢过程.
- 之前关于胆囊切除术和骨质疏松症风险的研究产生了相互矛盾的结果.
研究的目的:
- 研究先前胆囊切除术与骨质疏松症发病率之间的关联.
- 分析与胆囊切除术史有关的骨质疏松症风险因素.
主要方法:
- 英国生物银行的一项队列研究包括17603名接受胆囊切除术的参与者和35206名匹配的对照者.
- 使用ICD-10代码 (M80-82) 追踪骨质疏松发病率,平均随访时间为13.56年.
- 考克斯的比例回归模型评估了这种关联,并根据年龄,性别,BMI和维生素D水平进行了分组分析.
主要成果:
- 以前的胆囊切除术与女性骨质疏松症风险增加1.21倍和男性骨质疏松症风险增加1.45倍有关.
- 这种关联在40-55岁的女性中更为明显,BMI低 (<18.5公斤/米2),维生素D水平中等 (30-50nmol/ml).
- 没有发现与收入,教育,高血压或糖尿病有显著的相互作用.
结论:
- 胆囊切除术与患骨质疏松症的风险明显增加有关,即使考虑到混因素.
- 医疗保健提供者应考虑在有胆囊切除病史的患者中增加骨质疏松症风险.
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