甲状腺血清测量与高胆固醇血症在甲状腺腺体受试者之间的关联:一项回顾性跨部门研究
1Department of Thyroid Surgery, The First Hospital of China Medical University, Shenyang, Liaoning, People's Republic of China.
Diabetes, metabolic syndrome and obesity : targets and therapy
|November 6, 2023
概括
甲状腺刺激激素 (TSH) 和甲状腺过氧化酶抗体 (TPOAb) 的升高与高甲状腺患者的同类氨酸 (HCy) 水平有关. 这些甲状腺指标是高homocysteinemia (HHCy) 的独立风险因素.
科学领域:
- 内分泌学 在内分泌学.
- 临床化学 临床化学
- 内部医学 内部医学
背景情况:
- 同类氨酸 (HCy) 是一种与各种健康状况相关的氨基酸.
- 甲状腺功能在代谢过程中发挥作用,可能会影响HCy水平.
- 了解甲状腺状况和HCy之间的关系对于风险评估至关重要.
研究的目的:
- 为了研究血清甲状腺测量和同型半氨酸 (HCy) 水平之间的关联.
- 为了确定甲状腺指标是否是甲状腺参与者中高同位素蛋白血症 (HHCy) 的风险因素.
主要方法:
- 这是一项回顾性研究,分析了来自775名无甲状腺患者的医院信息系统数据.
- 排除甲状腺功能障碍或最近使用影响血清HCy.Cy的药物的人.
- 用甲状腺刺激激素 (TSH) 和甲状腺过氧化酶抗体 (TPOAb) 的多变量回归分析,与没有HHCy的参与者之间的甲状腺功能测量结果的比较.
主要成果:
- 与对照组相比,患有高homocysteinemia (HHCy) 患者的血清TSH水平和TPOAb阳性率显著提高.
- 血清HCy水平升高与较高的TSH四分位数和TPOAb阳性相关.
- 多变量回归确定了高TSH和TPOAb阳性作为高HCy和HHCy患病率的独立风险因素.
结论:
- 患有HHCy的患者表现出显著更高的TSH水平和TPOAb阳性.
- 升高的TSH和阳性TPOAb被证实是HCy度升高和HCy风险的独立风险因素.
- 在TPOAb标位和HCy度或HCy患病率的线性增加之间没有发现明确的关联.
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