氧化石烯功能化细菌纤维素-凝水凝与黄素释放和动力学:体外生物评估
Muhammad Umar Aslam Khan1,2, Goran M Stojanović3, Roselinda Ab Rehman4
1Biomedical Research Center, Qatar University, Doha 2713, Qatar.
ACS omega
|November 6, 2023
概括
由细菌纤维素,凝和氧化石墨烯制成的新生物活性水凝显示出作为先进的伤口包裹的前景. 这些材料具有出色的生物相容性和抗菌特性,可有效治愈伤口.
科学领域:
- 生物材料科学 生物材料科学
- 聚合物化学 聚合物化学
- 纳米技术 纳米技术
背景情况:
- 基于生物聚合物的生物活性水凝为伤口愈合提供了卓越的特性.
- 关键性质包括水友性,可调性力学,生物降解性和生物相容性.
- 先进的伤口包裹对于有效的组织再生至关重要.
研究的目的:
- 制造和表征用于伤口愈合应用的新型生物活性水凝.
- 评估结构性,机械性,胀性和药物释放性.
- 评估开发的水凝的细胞相容性,抗菌疗效和血液相容性.
主要方法:
- 使用细菌纤维素 (BC),凝和石墨烯氧化物 (GO) 制造水凝.
- 通过水热方法和与四乙烯正酸盐 (TEOS) 交叉连接合成GO功能化BC (GO-f-BC).
- 使用FTIR,SEM,UTM进行表征;胀分析;弗朗茨扩散用于黄素释放;细胞活力测试 (3T3纤维细胞);抗菌测试;血液溶解测试.
主要成果:
- 成功制造具有可调节性质的生物活性水凝.
- 在水性介质中观察到的最大胀.
- 黄素的释放遵循希克森-克劳尔动力学,释放高达69.32%.
- 有前途的细胞活力,增殖,显著的抗菌活性和血液相容性 (<0.5%的血液溶解).
结论:
- 开发的生物活性水凝显示出作为先进的伤口包裹材料的巨大潜力.
- 结合BC,凝和GO,形成了一种用于伤口管理的多功能材料.
- 需要进一步的研究来探索它们在伤口愈合应用中的临床疗效.
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