基因型-环境的相互作用在母亲饮酒与后代情绪和行为问题之间的关联中起作用
Laurie John Hannigan1,2,3, Ingunn Olea Lund2,4, Adrian Dahl Askelund1,2
1Nic Waals Institute, Lovisenberg Diaconal Hospital, Oslo, Norway.
Psychological medicine
|November 6, 2023
概括
当考虑遗传因素时,母亲的风险饮酒与儿童的情绪和行为问题的关联是最小的. 遗传变异并没有缓解母亲饮酒与儿童结局之间的联系.
科学领域:
- 精神病学是一个精神病学.
- 遗传学 是一个遗传学.
- 发展心理学 发展心理学
背景情况:
- 母亲有风险饮酒与孩子的情绪和行为问题有关.
- 遗传混和基因与环境的相互作用仍然不清楚.
- 这些代际关联背后的机制需要研究.
研究的目的:
- 评估基因型与环境 (G × E) 相互作用对母亲的危险饮酒和儿童的结果.
- 为了解释母亲和后代之间的共同遗传风险 (GE相关性).
- 调查与环境敏感性相关的遗传变异的作用.
主要方法:
- 利用挪威母亲,父亲和儿童队列研究的数据 (109,727名儿童,90,873名母亲).
- 母亲自我报告的酒精消费;儿童的情绪和行为问题在1.5岁,3岁和5岁时被报告.
- 环境敏感性的儿童多基因分数 (PGS) 被用作调节者.
主要成果:
- 母亲饮酒与儿童结局之间的关联在控制混因子后显著减弱.
- 没有测量的混将关联减少到接近零.
- 没有观察到通过多基因分数调整的暴露效应的显著缓解.
结论:
- 对G × E相互作用缺乏强有力的证据表明,它可能不是主要的机制.
- 样本中的统计能力不足或良性暴露性也可以解释这些发现.
- 需要进一步的研究,以充分阐明风险的代际传播.
关键词:
酒精饮料 酒精饮料 酒精饮料 酒精饮料摩巴巴是什么意思 摩巴巴是什么意思行为问题 行为问题情绪问题 情绪问题问题外化问题.基因型 环境 相互作用基因型 环境 相互作用内部化问题 内部化问题孕产妇喝酒的情况多基因分数的多基因分数更多相关视频
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