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Published on: October 11, 2018
在怀孕期间有睡眠呼吸障碍的孕妇患有出生缺陷的风险
Katherine Pressman1, Anthony M Kendle1, Tara M Randis1,2
1Department of Obstetrics and Gynecology, Morsani College of Medicine, University of South Florida, Tampa, Florida, USA.
怀孕早期的睡眠呼吸障碍 (SDB) 可能与出生缺陷有关,但需要进一步的研究来确认这种联系并了解特定缺陷的风险.
科学领域:
- 产科和妇科 产科和妇科
- 睡眠医学 睡眠医学
- 围产期健康 围产期健康
背景情况:
- 睡眠呼吸障碍 (SDB) 影响高达25%的孕妇.
- SDB与胰岛素抵抗和炎症有关,这些因素与出生缺陷有关.
研究的目的:
- 调查怀孕期间睡眠呼吸障碍 (SDB) 与非染色体出生缺陷风险之间的联系.
主要方法:
- 从无卵性怀孕结果研究中对2106名参与者的二次分析:监测即将成为母亲.
- 家庭睡眠呼吸暂停测试用于诊断SDB (呼吸暂停-呼吸暂停指数≥5).
- 出生缺陷是从国家出生缺陷预防网络年度报告中确定出来的.
主要成果:
- 总的出生缺陷率为3.1%.
- 在没有SDB的妇女 (3.0%) 和怀孕中期SDB的妇女 (3.4%) 中,出生缺陷的患病率相似.
- 在怀孕早期患有SDB的妇女中观察到更高的患病率 (6.7%),但在调整为混因素后,这种差异在统计学上并不显著.
结论:
- 虽然怀孕早期的SDB显示出出生缺陷的患病率更高,但调整后的分析发现没有显著的关联.
- 需要进一步的研究来评估预孕和早期怀孕SDB对胎儿发育和特定出生缺陷的影响.
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