血清β-人类胆性淋巴激素水平与甲状腺代谢功能的相关性 孕妇患有妊娠激发症的甲状腺代谢功能
Haiyan Zheng1, Qian Wang1, Feng Chen2
1Department of Endocrinology, Renmin Hospital, Hubei University of Medicine, Shiyan, Hubei, China.
The Chinese journal of physiology
|November 6, 2023
概括
高血清β-人类胆性淋巴激素 (β-hCG) 水平在超重症 (HG) 中与甲状腺功能和HG严重程度相关. 这些标记物与甲状腺激素一起,显示出HG的诊断价值.
科学领域:
- 生殖内分泌学 生殖内分泌学
- 甲状腺学 甲状腺学
- 孕产妇和胎儿医学 孕产妇和胎儿医学
背景情况:
- 血清β-人类胆管性腺激素 (β-hCG) 是早期妊娠异常的已知标志物.
- 妊娠激发症 (HG) 是一种严重的怀孕中恶心和吐的形式,可能与荷尔蒙变化有关.
研究的目的:
- 为了研究血清β-hCG水平和甲状腺代谢功能的相关性,在怀孕妇女与HG.
- 为了评估β-hCG和甲状腺功能标志物的诊断价值,用于HG.
主要方法:
- 血清β-hCG,自由甲状腺素 (FT4),自由三甲状腺素 (FT3),甲状腺刺激激素 (TSH) 和与甲状腺有关的抗体 (TPOAb,TRAb,TgAb) 在91名HG患者和84名对照人群中被测量.
- 视觉模拟尺度 (VAS) 评估了HG的严重程度.
- 使用了皮尔森相关性和ROC曲线分析.
主要成果:
- 与对照组相比,HG患者的β-hCG,FT3,FT4,TPOAb,TRAb,TgAb和VAS得分较高,TSH水平较低.
- 在HG患者的血清β-hCG水平与FT3,FT4,甲状腺抗体和VAS得分正相关,与TSH和妊娠年龄负相关.
- 甲状腺激素和抗体水平,以及β-hCG,随着HG患者怀孕的进展而下降.
结论:
- 血清β-hCG的HG异常升高,与疾病严重程度和甲状腺功能障碍相关.
- β-hCG和甲状腺功能标志物具有显著的临床诊断价值.
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