伴随性疾病,营养和表现状况对扩散大B细胞淋巴瘤患者的预后影响
B Saglam1, M Albayrak2, A Yıldız3
1Department of Hematology, Liv Hospital Gaziantep, Gaziantep, Turkey.
Nigerian journal of clinical practice
|November 6, 2023
概括
营养状况,并发症和表现状况显著影响分散型大B细胞淋巴瘤 (DLBCL) 患者的结果. 这些因素,包括ECOG和白蛋白水平,是整体生存和无进展生存的独立预后标志物.
科学领域:
- 在瘤学瘤学.
- 血液学 血液学 血液学
- 临床研究 临床研究
背景情况:
- 扩散性大B细胞淋巴瘤 (DLBCL) 是一种严重的血液性恶性瘤.
- 影响DLBCL患者结果的预后因素需要进一步调查.
研究的目的:
- 调查营养状况,并发症和表现状况对DLBCL患者的影响.
- 确定DLBCL的独立预后标志物.
主要方法:
- 在2009-2018年间诊断出112名DLBCL患者的回顾性研究.
- 使用年龄调整的查尔森并发症指数 (CCI-A),白蛋白水平和ECOG分数进行评估.
- 进行了考克斯回归分析,以确定独立的风险因素.
主要成果:
- 具有CCI-A> 4的患者的无进展生存期 (PFS) 和整体生存期 (OS) 显著降低.
- ECOG性能状态和白蛋白水平被确定为OS和PFS的独立风险因素 (P<0.05).
- 大多数患者 (69.1%) 的ECOG分数为0-1,57.1%的患者在随访时是幸存者.
结论:
- 在DLBCL中,CCI-A,ECOG性能状态和营养状态都是独立的预后标记.
- 这些易于评估的参数应纳入DLBCL患者的初始评估.
- 这些因素的早期评估可以帮助预测患者的预后,并指导治疗策略.
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