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在妇科癌症的抗瘤治疗后,休息能量消耗的变化:一项前性试点研究
Karolina Alvarez-Altamirano1, Karina Miramontes-Balcon2, Carolina Cárcoba-Tenorio3
1Clinical Nutrition Ward. Hospital General de México.
Nutricion hospitalaria
|November 6, 2023
概括
在抗瘤治疗后,在患有妇科癌症的妇女中,无论治疗类型如何,休息能量消耗 (REE) 都下降了. 目前关于REE准确性的建议需要在这个患者群体中进行进一步的研究.
科学领域:
- 在瘤学瘤学.
- 代谢过程中的代谢.
- 临床营养学 临床营养学
背景情况:
- 能量代谢对癌症患者至关重要,但抗瘤治疗对休息能量消耗 (REE) 的影响仍然不清楚,特别是在女性中.
- 接受各种抗瘤疗法的妇科癌症患者需要进一步调查其代谢变化.
研究的目的:
- 在患有妇科癌症的妇女中,在第一轮抗瘤治疗前后使用间接热量计 (IC) 评估休息能量消耗 (REE).
- 将REE与欧洲临床营养和新陈代谢学会 (ESPEN) 的指导方针进行比较,并评估生活质量 (QoL) 的变化.
主要方法:
- 一项观察性纵向研究,涉及54名患有妇科癌症的妇女,接受放射治疗 (RT),化疗 (CT) 或化疗辐射治疗 (CRT).
- 在两个时间点 (T0和T1) 用IC测量了REE.
- 包括Kruskal-Wallis和Bland-Altman在内的统计分析将REE与ESPEN建议进行比较,并评估准确性.
主要成果:
- 从T0到T1的总患者群体中观察到REE的统计学显著下降 (p = 0.018).
- 在REE变化和特定抗癌疗法组 (RT,CT,CRT) (p > 0.05) 之间没有发现显著的关联.
- 生活质量 (QoL) 在治疗后没有显著变化. 与总能耗 (TEE) 相比,标准REE建议 (25和30 kcal/kg) 的准确性低于30%.
结论:
- 在患有妇科癌症的妇女中,抗瘤治疗导致REE的减少,而不管服用了什么疗法.
- 需要进行进一步的研究,以验证ESPEN建议在癌症患者中估计TEE的准确性,考虑到IC测量和临床因素.
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