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多发性骨髓瘤中的肥胖悖论:来自多发性骨髓瘤研究基金会 (MMRF) 数据集的报告

Liang Ren¹, Tianhong Xu¹, Yuhong Ren¹

¹Department of Hematology, Zhongshan Hospital, Fudan University, Shanghai, P. R. China.

Cancer medicine

|November 6, 2023

概括

肥胖可能会对多发性骨髓瘤 (MM) 患者产生悖论性的影响,年轻的肥胖个体的生存率更差. 肥胖患者的整体治疗反应率也较高.

科学领域:

血液学血液学血液学
在瘤学瘤学.
临床研究临床研究

背景情况:

肥胖是多发性骨髓瘤 (MM) 的已确定的危险因素.
关于肥胖MM患者的临床过程的了解有限.
调查肥胖对MM进展和治疗的影响至关重要.

研究的目的:

评估肥胖多发性骨髓瘤 (MM) 患者的临床过程.
为了比较肥胖和正常体重的MM患者在特征,治疗和生存方面.
确定肥胖MM患者的特定子组,这些患者可能会经历不同的结果.

主要方法:

来自MMRF coMMpass数据集的568名MM患者的回顾性分析.
根据诊断时的身体质量指数 (BMI) 将患者分为正常和肥胖的组.
评估基线特征,细胞遗传异常,治疗变异性和生存结果.

主要成果:

肥胖的MM患者中男性比例较高 (59.9%对50.4%).
65岁以下的肥胖MM患者的整体存活率 (OS) 显著下降.
肥胖的MM患者实现了更高的整体反应率 (ORR) (92.7%与88.6%) 和更快的最佳反应.

结论:

肥胖在多发性骨髓瘤的临床轨迹中起着复杂而矛盾的作用.
年轻的肥胖MM患者 (65岁以下) 面临较差的生存结果.
尽管子组生存率有差异,但肥胖与MM患者治疗反应率的改善有关.

关键词:

这就是为什么BMI是BMI.细胞遗传异常是异常的多发性骨髓瘤是多发性骨髓瘤的一种.肥胖的悖论肥胖的悖论预后预后预后

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