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活微生物摄入量与NAFLD之间的关联:来自NHANES 2003-2018年的证据

Chuanlei Fan¹, Yang He², Jian Yang¹

¹The First Clinical Medical College, Lanzhou University, Lanzhou, Gansu, China.

Journal of the American Nutrition Association

|November 6, 2023

概括

消费活微生物与非酒精性脂肪性肝病 (NAFLD) 的患病率较低有关. 这表明,饮食中的活微生物可能在管理NAFLD方面发挥作用.

科学领域:

微生物学和胃肠道学
代谢性疾病研究研究
营养科学营养科学

背景情况:

非酒精性脂肪肝 (NAFLD) 是一个日益严重的全球健康问题.
人们越来越认识到肠道微生物在代谢健康中的作用.
饮食因素,包括活微生物,可能会影响NAFLD的发展.

研究的目的:

调查饮食中的活微生物摄入量与NAFLD患病率之间的关联.
探索活微生物与各种代谢健康标志物之间的关系.

主要方法:

横截面研究设计. 截面研究设计.
在代表性成年人样本中分析含有活微生物的食物的饮食摄入量.
后勤回归来评估活微生物摄入量与NAFLD流行率之间的关联,调整为共变量.

主要成果:

含有活微生物的食物摄入量较高与较低的NAFLD患病率有显著的关联 (OR = 0.830,p < 0.001).
活微生物摄入与改善的代谢标记相关,包括降低血压,葡萄糖,BMI和LDL胆固醇,以及更高的HDL胆固醇.
在种族和吸烟子组中观察到显著的相互作用.

结论:

饮食中摄入活微生物与NAFLD的发病率降低有着强烈的相关性.
通过促进有益细菌来调节肠道微生物群,为NAFLD预防和治疗提供了一个潜在的战略.

关键词:

活微生物的摄入量尼汉斯 (NHANES) 是一个名人.肠道微生物肠道微生物非酒精性脂肪性肝病是什么?

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