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在早期发病的认知功能儿童的1型糖尿病
K Swaminathan1, Pamali Mahasweta Nanda1, Jaivinder Yadav2
1Department of Pediatrics, Postgraduate Institute of Medical Education and Research, Chandigarh, 160012, India.
Indian journal of pediatrics
|November 6, 2023
概括
患有早期1型糖尿病 (T1D) 的儿童表现出较低的认知功能和智商. 低血糖控制和严重的低血糖症与这些缺陷有关,突出显示了在年轻T1D患者中需要更好的管理.
科学领域:
- 儿科内分泌学 儿科内分泌学
- 神经科学是一个神经科学.
- 发展心理学 发展心理学
背景情况:
- 1型糖尿病 (T1D) 是一种慢性自身免疫性疾病,需要终身治疗.
- 早期发病的T1D,在6岁之前被诊断出来,在生长和发育方面提出了独特的挑战.
- 患有T1D的儿童的认知功能是一个日益关注的领域,特别是在多样化的人口中.
研究的目的:
- 评估早期T1D诊断的印度儿童的认知功能.
- 为了确定影响这种脆弱群体认知表现的因素.
- 为了比较T1D早期发病儿童和健康对照儿童之间的认知结果.
主要方法:
- 一项涉及60名患有早期T1D的儿童 (发病年龄<6岁,疾病持续时间≥2年) 和60名年龄/性别匹配的对照的横截面研究.
- 认知评估使用了马林的印度儿童智力表 (MISIC).
- 排除标准包括出生窒息,智力障碍,综合征状况和先前存在的精神疾病.
主要成果:
- 患有早期T1D的儿童在大多数MISIC子测试中得分明显较低,包括口头,表现和整体智商 (IQ).
- 较差的血糖控制 (HbA1c > 9%),严重低血糖病史和自上次糖尿病酸性 (DKA) 发作以来的较短持续时间与神经认知评分的降低有关.
- 在T1D组的平均智商为100.62±3.26,而对照组的平均智商为103.23±1.22.
结论:
- 早期发病的T1D与认知领域和整体智商的显著缺陷有关.
- 低于最佳的血糖控制,高血糖变异性和严重的低血糖症被确定为影响这些儿童认知发展的关键风险因素.
- 建议进行纵向研究,以进一步阐明影响T1D儿童认知结果的因素的复杂相互作用.
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