一种适合儿童的抗感染口香糖配方:设计,物理化学,微机械和味觉感官评估
Emma A Kean1, Oluwatoyin A Adeleke2
1College of Pharmacy, Faculty of Health, Dalhousie University, B3H 4R2, Halifax, NS, Canada.
Drug delivery and translational research
|November 6, 2023
概括
一种新的乳糖配方 (P-GDF) 提供了一种儿童友好的方法,用于治疗结核病. 这种可食用的药物输送系统改善了儿科患者的口味和易用性.
科学领域:
- 制药科学 制药科学
- 药物输送系统 药物输送系统
- 儿科医学 儿科医学
背景情况:
- 儿童友好的药物配方对于有效的儿科结核病 (TB) 管理至关重要.
- 传统的结核病药物在儿童的管理和遵守方面存在挑战.
- 可配方提供了诸如口味掩饰和易于使用等优势.
研究的目的:
- 开发和表征一种新的聚合物药物配方 (P-GDF) 用于儿科异化物输送.
- 创建一个有吸引力的,美味的,稳定的配方,以改善儿童的治疗坚持.
主要方法:
- 利用结合的固体液体分散和取决于温度的sol-gel技术来创建P-GDF.
- 将第一线抗结核病药物伊索尼亚齐德 (isoniazid) 纳入母体中.
- 评估了物理,机械,结构,药物封装,释放动力学,口味掩饰和稳定性.
主要成果:
- 在尺寸上,P-GDF (FlexiChew) 是紧的,轻量级的,机械上坚固的,易于操作.
- 达到高的异化封装效率 (≈101.57%) 和快速释放药物 (≈100%在75分钟内).
- 证明有效的口味掩饰和可口性,确定了最佳的储存条件.
结论:
- 成功制造了一种适合儿童的,含有异化的制剂 (P-GDF),用于儿科结核病治疗.
- P-GDF显示出增强患者坚持治疗和治疗疗效的潜力.
- 这种新的配方解决了儿科结核病管理的重大挑战.
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