骨外三门置换和一年的结果:TRISCEND研究
Susheel Kodali1, Rebecca T Hahn1, Raj Makkar2
1Division of Cardiology, Columbia University Irving Medical Center, 161 Fort Washington Avenue, NewYork, NY 10032, USA.
European heart journal
|November 6, 2023
概括
透管三管置换显著改善了严重三管吐患者的症状和生活质量. 一年后,EVOQUE系统证明了TR的持续减少和积极的临床结果.
科学领域:
- 心脏病学 心脏病学
- 干预心脏病学 干预心脏病学
- 医疗器械 医疗器械
背景情况:
- 症状,严重的三腹吐 (TR) 显著影响患者的功能状态和生活质量.
- 通过导管三管 (TV) 的干预措施显示了改善结果的早期承诺.
- 需要更长期的数据来证实电视干预的持续益处.
研究的目的:
- 通过使用 EVOQUE 系统来评估跨导管电视更换的安全性和性能.
- 评估患有症状,中度至重度TR的患者的一年结果.
- 分析干预后功能状态和生活质量的改善.
主要方法:
- 前性,单臂,多中心的TRISCEND研究.
- 招募了176名患者,尽管接受了医疗治疗,但仍有症状的TR.
- 评估主要不良事件,TR等级,血液动力学和临床参数到一年.
主要成果:
- 97.6%的患者实现了TR降低至≤轻度.
- 观察到中风体积 (10.5毫升) 和心脏输出量 (0.6升/分钟) 的显著增加.
- 93.3%的人达到NYHA I或II级,生活质量明显改善,步行距离6分钟.
结论:
- 跨关节EVOQUE跨导管电视替换在老年,并发病患者中提供持续的TR降低.
- 该程序带来了显著的血液动力学改善,改善了临床,功能和生活质量的结果.
- 一年后观察到高生存率 (90.9%) 和低心力衰竭住院率 (10.2%).
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