假反应第四代人类免疫缺陷病毒在癌症患者中进行测试
Chia-Yu Chiu1,2, Khalis Mustafayev2, Micah M Bhatti3
1Department of Infectious Diseases, University of Texas Health Science Center at Houston, Houston, Texas, USA.
概括
近三分之一的癌症患者经历了错误反应的第四代 (第四代) 人类免疫缺陷病毒 (HIV) 测试. 医疗保健提供者应该认识到这些癌症患者的高发病率,以改善艾滋病毒查咨询和减少患者的痛苦.
科学领域:
- 在瘤学瘤学.
- 传染性疾病 传染性疾病
- 临床诊断 临床诊断 临床诊断
背景情况:
- 第四代 (第四代) 人类免疫缺陷病毒 (HIV) -1/2抗体/抗原 (Ab/Ag) 免疫测试是敏感的HIV查工具.
- 错误反应结果发生在多达20%的患者中,癌症群体的数据有限.
研究的目的:
- 评估癌症患者中错误反应的第四代艾滋病毒检测结果的频率和预测因素.
- 评估错误反应结果对癌症治疗和患者精神困扰的影响.
主要方法:
- 在一个主要的癌症中心对癌症患者进行反应性第四代艾滋病毒检测的回顾性研究 (2016年3月-2023年1月).
- 分析患者特征,真反应与假反应结果 (CDC标准) 和预测因子的后勤回归.
- 对癌症治疗延迟和与错误反应结果相关的精神痛苦的评估.
主要成果:
- 在272名癌症患者中,有反应性第四代HIV检测,29%的结果是错误的.
- 虚假反应的预测因素包括年龄超过60岁,女性性别,特定种族/种族,梅毒共感染和植物类药物治疗.
- 癌症治疗没有延迟,但26%的错误反应结果的患者经历了精神困扰.
结论:
- 错误反应的第四代艾滋病毒查结果在癌症患者中很常见,发生在近三分之一的病例中.
- 医生需要意识到这些高的错误反应率,以告知艾滋病毒检测咨询,特别是低风险个体.
- 了解这些比率可以帮助减轻与艾滋病毒查相关的不必要的患者焦虑和痛苦.
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