RVdb:一个全面的资源和分析平台,用于犀牛病毒研究
Peng Zhao1, Siyu Zhou1, Panpan Xu1
1NHC Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 102629, P.R. China.
Nucleic acids research
|November 6, 2023
概括
鼻病毒 (RV) 是呼吸系统疾病的常见原因,表现出显著的遗传多样性. 一个新的资源,RVdb,提供了一个全面的平台来分析RV菌株,并帮助公共卫生监测.
科学领域:
- 病毒学 病毒学
- 生物信息学是一种生物信息学.
- 基因组学就是基因组学.
背景情况:
- 犀牛病毒 (RV) 是人类呼吸道感染的主要原因,包括普通感冒和喘恶化,导致社会成本显著.
- RV的高突变率和基因组多样性,有174个已识别的血清型,使流行病监测和疾病调查复杂化.
研究的目的:
- 介绍RVdb,一个关于犀牛病毒 (RV) 菌株,序列,蛋白质结构和出版物的全面数据资源.
- 为分析RV遗传特征和支持公共卫生工作提供综合生物信息学工具.
主要方法:
- 开发RVdb,这是一个基于网络的资源,包含26,909个RV菌株和相关数据.
- 集成基于Web的实用程序,用于浏览,搜索,序列注释,多重序列对齐 (MSA),遗传树构建,BLAST和血清型.
主要成果:
- RVdb提供了一个用户友好的平台,提供了关于RV菌株和遗传信息的大量数据.
- 综合生物信息学工具有助于分析RV遗传多样性和特征.
结论:
- 对于研究RV遗传多样性的研究人员来说,RVdb是一个有价值和强大的平台.
- 该资源支持病毒学家和流行病学家监测和追踪RV相关的传染病,以促进公共卫生.
相关概念视频
Bacteriophages of the Human Virome
Bacteriophages are found throughout the human body. They may even outnumber eukaryotic viruses, forming an important and dynamic component of the human virome. Indeed, phages represent the most abundant viral entities, with densities in the gut reaching up to 10⁹ particles per gram of fecal matter, and many belonging to orders such as Caudovirales and Microviridae, while a substantial proportion remains unclassified as viral “dark matter.”Lysogeny and Genetic ExchangeIn the gut, bacteriophages...
Respiratory Syncytial Virus Disease
Human respiratory syncytial virus (RSV) is a widespread pathogen that primarily targets infants and young children but also poses a serious health risk to elderly and immunocompromised individuals. Belonging to the Pneumoviridae family, RSV is a negative-sense, single-stranded RNA virus within the Pneumovirus genus. Its global health burden is significant, with millions of cases annually resulting in hospitalizations and mortality, particularly in resource-limited settings. Although most...


