相关实验视频

Updated: Jul 11, 2025

Single-Molecule Fluorescence Visualization of DNA Polymerase Dynamics at G-Quadruplexes
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Single-Molecule Fluorescence Visualization of DNA Polymerase Dynamics at G-Quadruplexes

Published on: April 4, 2025

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基因变异在G-四方体形成序列影响人类疾病相关基因的转录

Agustín Lorenzatti1, Ernesto J Piga1, Mauro Gismondi2

  • 1Instituto de Biología Molecular y Celular de Rosario (IBR), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET) - Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario (UNR), Ocampo y Esmeralda, Rosario S2000EZP, Santa Fe, Argentina.

Nucleic acids research
|November 6, 2023
PubMed
概括

单核酸变体 (SNVs) 影响基因促进器区域的G四重复体 (G4s) 可以影响转录和疾病风险. 这项研究确定了与疾病相关的G4变异,为精准医学诊断和治疗提供了潜力.

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