抗疟药对狼性炎的临床结果的影响
Óscar R Peña-Vizcarra1, María Fernanda Zavala-Miranda1, Bernardo Juárez-Cuevas1
1Department of Nephrology and Mineral Metabolism, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.
Rheumatology (Oxford, England)
|November 6, 2023
概括
抗疟疾药物改善治疗反应,并减少狼性炎 (LN) 患者的炎和功能衰竭. 然而,由于潜在的视网膜病变风险,定期进行眼科检查至关重要.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 类风湿病学 类风湿病学
- 药理学 药理学是指药理学的学科.
背景情况:
- 狼性炎 (LN) 是系统性红斑狼的一种严重并发症.
- 抗疟疾药物是LN治疗的基石,但它们的长期影响需要进一步评估.
研究的目的:
- 评估LN患者抗疟药物的疗效,包括治疗反应,炎和疾病进展.
- 确定改变抗疟疾药物的作用的因素,并评估相关的毒性.
主要方法:
- 对424名活检证明的LN患者进行了回顾性研究,随访时间超过3年.
- 对人口统计,临床,实验室,遗传病学和治疗数据的分析.
- 时间到事件分析和考克斯回归来评估抗疟疾药物的使用 (使用者与非使用者,流行与事件使用,药物类型) 和结果.
主要成果:
- 抗疟疾药的使用与更高的完整治疗反应 (aHR 1.57),较少的炎 (aHR 0.63) 和减少衰竭进展 (aHR 0.37) 相关联.
- 随着流行/事件使用和氧化,根据基线EGFR和组织学修改的基线EGFR和组织学修改的保护效应被注意到.
- 长期使用抗疟疾药物显示,视网膜病变的累计发病率在3年后为1.7%,5年后为5.7%,7年后为8.8%.
结论:
- 抗疟疾药物显著改善LN患者的治疗反应和结局.
- 尽管有好处,但对有毒黄斑病的仔细监测至关重要,需要每年进行眼科检查.
关键词:
这是一种抗疟疾药物.氨酸 (Chloroquine) 的使用情况一个火焰灯.氧化chloroquine 的使用情况功能衰竭 功能衰竭是什么?狼性炎是一种神经炎症.结果就是结果.响应 响应 响应 响应系统性红血性狼 (Systemic Lupus Erythematosus) 是一种全身性狼.更多相关视频
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