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Updated: Jul 11, 2025

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使用线性分解模型 (LDM) 分析微生物组数据的组成分析

Yi-Juan Hu1, Glen A Satten2

  • 1Department of Biostatistics and Bioinformatics, Emory University, Atlanta, GA 30322, United States.

Bioinformatics (Oxford, England)
|November 6, 2023
PubMed
概括

我们介绍了以线性分解模型为中心的日志比率 (LDM-clr),这是分析微生物组数据的新方法. 这种方法允许对不同共变量和研究设计的差异丰度进行组成分析.

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Advancements in molecular biology have revolutionized the identification and characterization of bacteria, with multiple methods leveraging DNA sequencing for enhanced precision. As sequencing technologies improve and costs decline, these approaches are increasingly used in clinical, environmental, and evolutionary studies.Multilocus Sequence Typing (MLST) examines several housekeeping genes, essential chromosomal genes encoding cellular functions, to distinguish strains. Approximately...
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