与疼痛相关的顶部唤起潜力. 表面电气与热刺激的比较
Roberto J Guiloff1,2,3, Mario Campero1,3, Gonzalo R Barraza3
1Faculty of Medicine University of Chile, Santiago, Chile.
概括
与疼痛相关的电刺激唤起潜力 (PREPse) 可以有效地测量Aδ纤维功能,为诊断神经病痛提供了一个比接触热唤起潜力更容易获得的临床工具.
科学领域:
- 神经科学是一个神经科学.
- 临床电生理学 临床电生理学
背景情况:
- 诊断神经病痛和小纤维神经病变依赖于识别感知纤维异常.
- 目前的评估方法包括激光,接触热或专用电极,这些电极可能难以获得.
- 作为传统表面电刺激 (PREPse) 的替代方案,研究了与疼痛相关的唤起潜力.
研究的目的:
- 为了确定PREPse是否可以索引Aδ afferent神经活动,尽管同时有Aß纤维激活.
- 为了比较PREPse的临床实用性与接触热引起的潜力 (CHEPS).
主要方法:
- 28名健康受试者接受了顶部 (Cz-A1/A2) 记录.
- 用环电极和杯电极对手指,脚和皮肤进行电刺激.
- 接触热刺激和压缩缺血性神经阻塞也被使用.
主要成果:
- PREPse显示了与Aδ纤维一致的外围速度.
- PREPse的幅度随着疼痛强度的增加而增加,随着刺激频率的增加而减少.
- 与CHEPS相比,PREPse显示了较早的N1和N2峰值,具有类似的间峰延迟,并在Aδ纤维封锁后变得无法记录.
结论:
- PREPse的结果表明Aδ纤维的直接刺激,通过传导速度和神经阻断得到验证.
- 在PREPse中,幅度与疼痛的关系和频率效应与其他唤起潜在的方法所见的效应相匹配.
- 需要在临床环境中进一步验证PREPse的体感路径病变,以确定其对CHEPS的有用性.
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