心血管疾病中的脂肪组织:从基础科学到临床翻译
Murray D Polkinghorne1,2, Henry W West1,2,3, Charalambos Antoniades1,2
1Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom;
Annual review of physiology
|November 6, 2023
概括
脂肪组织不再被视为仅仅用于脂肪储存;它与心脏和血管积极沟通. 新的成像和疗法强调了它在代谢和心血管健康中的作用.
科学领域:
- 心血管科学 心血管科学
- 代谢健康 代谢健康
- 脂肪组织生物学 脂肪组织生物学
背景情况:
- 历史上被视为惰性脂肪储存,脂肪组织现在被认为是其活跃的内分泌和信号作用.
- 脂肪组织通过双向通信在调节代谢健康和心血管功能方面发挥着至关重要的作用.
- 在脂肪组织储存中存在功能和形态异质性,影响它们对系统生理学的贡献.
研究的目的:
- 审查对脂肪组织在代谢和心血管健康中的作用的不断变化的理解.
- 突出脂肪组织与心血管系统之间的沟通.
- 讨论脂肪组织表型切换和新兴治疗策略的影响.
主要方法:
- 关于脂肪组织生物学及其与心血管系统的相互作用的当前文献的综述.
- 讨论用于可视化脂肪组织变化的新型成像技术.
- 针对脂肪组织代谢的治疗方式的概述.
主要成果:
- 脂肪组织积极参与代谢调节和心血管平衡.
- 脂肪组织储存是异质的,并通过表型切换响应心血管信号.
- 新型成像可以量化这些变化,提供预后价值.
- 针对脂肪组织新陈代谢的疗法在降低心血管疾病风险方面表现有前途.
结论:
- 脂肪组织是一个动态的内分泌器官,对代谢和心血管健康至关重要.
- 了解脂肪组织的复杂信号和表型可塑性是开发新型心血管治疗的关键.
- 准脂肪组织代谢是预防和管理心血管疾病的有希望的治疗途径.
相关概念视频
01:24Obesity
509
The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
509
01:30Atherosclerosis I: Introduction
9
Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
9