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基于解剖学技术的术后克罗恩病内镜复发率:系统性审查和元分析
Olga Maria Nardone1,2, Giulio Calabrese3, Brigida Barberio4
1Gastroenterology, Department of Public Health, School of Medicine, Federico II University of Naples, Naples, Italy.
Inflammatory bowel diseases
|November 6, 2023
概括
与传统方法相比,Kono-S解剖术技术显著降低了克罗恩病患者在乳房切除后内镜术后复发的可能性. 这一发现表明Kono-S可能是管理克罗恩病复发的首选手术方法.
科学领域:
- 胃肠病学 胃肠病学
- 手术瘤学手术瘤学
- 炎症性肠道疾病研究研究
背景情况:
- 经过大眼切除的克罗恩氏病 (CD) 患者面临高内镜术后复发率 (ePOR),在六个月内从40-70%不等.
- 人们越来越多地认为,解剖器的配置是影响ePOR的因素.
- 科诺-S解剖解剖已经成为减轻ePOR风险的潜在策略,但跨多种解剖解剖类型的比较数据仍然有限.
研究的目的:
- 在CD患者中,系统地审查和元分析不同类型的乳头结肠瘤对ePOR的影响.
- 为了比较Kono-S解剖切除与常规眼解剖切除技术之间的ePOR速率.
主要方法:
- 在PubMed和Embase进行了系统的搜索,一直持续到2023年1月,搜索报告解瘤类型和ePOR率的研究.
- 研究被分类为解剖解剖类型:传统 (侧对侧,端对端,端对侧) 与Kono-S.
- 使用随机效应建模计算了ePOR的聚合发病率.
主要成果:
- 分析了包括2087名CD患者在内的17项研究.
- 在≥6个月后,ePOR的整体综合发病率为37.2%.
- 与常规解剖相比 (42.6%),科诺-S解剖显示了较低的聚合ePOR发生率 (24.7%).
结论:
- 与传统技术相比,科诺-S大肠瘤解剖学表明,在手术后六个月或更长时间内,ePOR的可能性降低了.
- 实施Kono-S解剖切除可能是有益的,特别是在具有挑战性的CD病例中.
- 建议通过大规模随机对照试验进行进一步验证,以确认这些发现.
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